Evidence map›Paper›PMID 25419505›Full record

ArticleDrug delivery and translational research2011

Prevention of

Jeremy S Blum, Caroline E Weller, Carmen J Booth, Imran A Babar, Xianping Liang, Frank J Slack, W Mark Saltzman

Open access · greenAbstract read
In one paragraph

Article in Drug delivery and translational research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Nanoparticle-based drug delivery to the vagina: a review.Journal of controlled release : official journal of the Controlled Release Society · 2014
    Review
  10. Controlled release for local delivery of drugs: barriers and models.Journal of controlled release : official journal of the Controlled Release Society · 2014
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jeremy S BlumDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
Caroline E WellerDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
Carmen J BoothSection of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
Imran A BabarDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Xianping LiangDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Frank J SlackDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
W Mark SaltzmanDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
Yale University · US

Funding

Molecular and Cellular Transport in MucusR01EB000487 · NIBIB · YALE UNIVERSITY · PI IWASAKI, AKIKO, SALTZMAN, W. MARK · 2002 to 2019
$5.0M
DNA Immunization in the Female Genital Tract Using A Controlled Delivery MatrixF32AI072942 · NIAID · YALE UNIVERSITY · PI BLUM, JEREMY S · 2008 to 2009
$108k
NIAID NIH HHS F32 AI072942NIBIB NIH HHS R01 EB000487
6 · The paper itself

Abstract

Primary squamous cell carcinoma of the vagina is an uncommon disease that often exhibits few symptoms before reaching an advanced stage. Topical intravaginal therapies for resolving precancerous and cancerous vaginal lesions have the potential to be non-invasive and safer alternatives to existing treatment options. Two factors limit the testing of this approach: lack of a preclinical intravaginal tumor model and absence of safe and effective topical delivery systems. In this study, we present both an inducible genetic model of vaginal squamous cell carcinoma in mice and a novel topical delivery system. Tumors were generated via activation of oncogenic

Indexed as

CamptothecinDrug deliveryInducible tumor modelKRASPolymer nanoparticlesPTENVaginal squamous cell carcinoma

Identifiers

PMID25419505
PMCPMC4239210
OpenAlexW1972275638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.