Evidence map›Paper›PMID 25419468›Full record

ArticleBone research

Kartogenin induces cartilage-like tissue formation in tendon-bone junction.

Jianying Zhang, James H-C Wang

Abstract read
In one paragraph

Article in Bone research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. [Application of Kartogenin in cartilage tissue engineering].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
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  8. Review
  9. Article
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  11. Review
  12. Article
  13. [Effect of Kartogenin combined with adipose-derived stem cells on tendon-bone healing after anterior cruciate ligament reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023
    Article
  14. Article
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  18. Article
  19. Strategies for promoting tendon-bone healing: Current status and prospects.Frontiers in bioengineering and biotechnology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jianying ZhangMechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, Mechanical Engineering and Materials Science, and Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA.
James H-C WangMechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, Mechanical Engineering and Materials Science, and Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Funding

Defining the role of tendon stem cells in the development of tendinopathyR01AR049921 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2002 to 2010
$2.8M
Repair of tendinopathic tendonsR01AR061395 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2011 to 2015
$1.8M
A tissue specific approach to enhance tendon repairR21AR060920 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2012 to 2013
$365k
NIAMS NIH HHS R01 AR049921NIAMS NIH HHS R01 AR061395NIAMS NIH HHS R21 AR060920
6 · The paper itself

Abstract

Tendon-bone junctions (TBJs) are frequently injured, especially in athletic settings. Healing of TBJ injuries is slow and is often repaired with scar tissue formation that compromises normal function. This study explored the feasibility of using kartogenin (KGN), a biocompound, to enhance the healing of injured TBJs. We first determined the effects of KGN on the proliferation and chondrogenic differentiation of rabbit bone marrow stromal cells (BMSCs) and patellar tendon stem/progenitor cells (PTSCs)

Identifiers

PMID25419468
PMCPMC4237211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.