Evidence map›Paper›PMID 25419434›Full record

ArticleInternational journal of clinical and experimental medicine2014

IL6-174G/C polymorphism and fracture risk.

Zhichang Zhang, Nengbin He, Tao Zhang

Abstract read
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In one paragraph

Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Zhichang ZhangDepartment of Orthopedics, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai 200233, China.
Nengbin HeDepartment of Orthopedics, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai 200233, China.
Tao ZhangDepartment of Orthopedics, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai 200233, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have examined the associations of polymorphism in interleukin-6 (IL6) with fracture risk. However, the results were conflicting. Thus, a meta-analysis was conducted to determine the relationship between IL6-174C/G polymorphism and risk of fracture. Databases including PubMed, EMBASE, Wanfang were searched. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. Six studies were included in this meta-analysis. IL6-174C/G polymorphism was associated with a significantly increased risk of fracture (OR=1.32; 95% CI, 1.10-1.58; I(2) =11%; Figure 1). In the subgroup analysis according to gender, women (RR=1.26; 95% CI, 1.09-1.46; I(2) =0%) was significantly associated with risk of fracture. In the age subgroup analysis, old population (RR=1.27; 95% CI, 1.11-1.48; I(2) =0%) showed increased fracture risk. However, young population did show increased risk of fracture (RR=1.95; 95% CI, 0.70-5.47; I(2) =51%). Postmenopausal women also showed an increased fracture risks (RR=1.24; 95% CI, 1.08-1.44; I(2) =0%). This meta-analysis suggested that IL6-174C/G polymorphism contributed the development of fracture.

Indexed as

Fractureinterleukin-6meta-analysispolymorphism

Identifiers

PMID25419434
PMCPMC4238497

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.