Massive plasmacytosis with severe marrow suppression induced by methimazole in Graves' disease patients: case report and literature review.

Feng Xiao, Chenying Li, Liangshun You, Wenbing Qian, Juying Wei

Open access · greenAbstract readCase Reports

In one paragraph

Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 27% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

A case of atypical Bartonella henselae infection in a patient with methimazole-induced agranulocytosis.BMJ case reports · 2015
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Feng XiaoDepartment of Hematology, The First Affiliated Hospital, Zhejiang University, College of Medicine Hangzhou, China.

Chenying LiDepartment of Hematology, The First Affiliated Hospital, Zhejiang University, College of Medicine Hangzhou, China.

Liangshun YouDepartment of Hematology, The First Affiliated Hospital, Zhejiang University, College of Medicine Hangzhou, China.

Wenbing QianDepartment of Hematology, The First Affiliated Hospital, Zhejiang University, College of Medicine Hangzhou, China.

Juying WeiDepartment of Hematology, The First Affiliated Hospital, Zhejiang University, College of Medicine Hangzhou, China.

First Affiliated Hospital Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antithyroid drugs (ATDs) induced leukopenia is commonly seen, but life-threatening agranulocytosis is a rare occurrence. Interestingly, agranulocytosis accompanied with plasmacytosis in bone marrow (BM) is rarer. In this study, we admitted a patient with Graves' disease who had been treated with 15 mg/d methimazole (MMI) for 42 days. She presented with agranulocytosis and plasmacytosis in bone marrow (BM). The patient withdrew taking MMI and was treated with broad-spectrum antibiotics and G-CSF. After two weeks, the patient's peripheral blood improvement was achieved and BM nearly returned to normal level. The case provides evidence that the elder patients with a high dose of MMI treatment are prone to develop agranulocytosis, especially the duration of treatment is longer than three months. We summary the literatures, and propose our new viewpoint on the mechanism of plasmacytosis in ATDs-induced agranulocytosis patients.

Indexed as

bone marrow suppressionGrave’s diseasemethimazolePlasmacytosis

Identifiers

PMID25419407

PMCPMC4238511

OpenAlexW2208006946

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.