ArticleOncoTargets and therapy2014
IL-1α -889 C/T polymorphism and cancer susceptibility: a meta-analysis.
Article in OncoTargets and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- The potential of cytokine polymorphisms as biomarkers for oral squamous cell carcinoma: a systematic review.Discover oncology · 2026Review
- Association of donor and recipient single-nucleotide polymorphisms of interleukin-1 gene with outcomes after allogeneic hematopoietic stem cell transplantation in childhood.Journal of cancer research and clinical oncology · 2025Article
- Novel Therapies Boosting T Cell Immunity in Epstein Barr Virus-Associated Nasopharyngeal Carcinoma.International journal of molecular sciences · 2020Review
- -148 C/T polymorphism of Axin2 contributes to a decreased risk of cancer: evidence from a meta-analysis.OncoTargets and therapy · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The -889 C/T polymorphism in the interleukin-1α (IL-1α) gene has been implicated in the risk of cancer, but the results are inconclusive. The present meta-analysis aimed to investigate the association between the -889 C/T polymorphism and cancer risk. A literature search in PubMed, Embase™, Web of Science™, Science Direct(®), SpringerLink, EBSCO, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases was carried out to identify studies investigating the association between IL-1α -889 C/T polymorphism and cancer risk. The odds ratio (OR) with 95% confidence interval (CI) were used to assess the strength of association. A total of 20 publications, involving 6,782 cases and 7,767 controls, were included in this meta-analysis. Combined analysis revealed a significant association between -889 C/T polymorphism and cancer risk under an allele model (OR =1.12, 95% CI =1.02-1.24, P=0.02), recessive model (OR =1.34, 95% CI =1.06-1.68, P=0.01), and homozygous comparison (OR =1.38, 95% CI =1.10-1.74, P<0.01). Subgroup analysis by ethnicity showed there was significant association between cancer risk and IL-1α -889C/T polymorphism in Asian populations under a recessive model (OR =2.57, 95% CI =1.11-5.98, P=0.03) and homozygous comparison (OR =2.60, 95% CI =1.12-6.04, P=0.03). Moreover, a subgroup analysis was conducted by source of control, and a statistically increased cancer risk was found in the hospital-based group, under a recessive model (OR =1.62, 95% CI =1.03-2.56, P=0.04) and homozygous comparison (OR =1.67, 95% CI =1.04-2.68, P=0.03). This meta-analysis suggests that IL-1α -889 C/T polymorphism contributes to cancer susceptibility. Further large and well-designed studies are needed to confirm this association.
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