Evidence map›Paper›PMID 25419039›Full record

ArticlePhysica A2015

Biophysics of protein-DNA interactions and chromosome organization.

John F Marko

Abstract read
In one paragraph

Article in Physica A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Nucleosomes play a dual role in regulating transcription dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
  3. Review
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  12. Facilitated dissociation of transcription factors from single DNA binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  13. Review
  14. Molecular Mechanism of Facilitated Dissociation of Fis Protein from DNA.Journal of the American Chemical Society · 2016
    Article
  15. Article
  16. Single-molecule fluorescence studies on DNA looping.Methods (San Diego, Calif.) · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

John F MarkoDepartment of Physics & Astronomy and Department of Molecular Biosciences, Northwestern University, Evanston, Illinois USA 60208.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
TRANS-NETWORK PROJECTSU54CA143869 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WIDOM, JONATHAN · 2009 to 2013
$12.8M
Activities of nucleoprotein complexes visualized in single-molecule experimentsR01GM105847 · NIGMS · NORTHWESTERN UNIVERSITY · PI MARKO, JOHN F · 2013 to 2025
$2.5M
NCI NIH HHS P30 CA060553NCI NIH HHS U54 CA143869NIGMS NIH HHS R01 GM105847
6 · The paper itself

Abstract

The function of DNA in cells depends on its interactions with protein molecules, which recognize and act on base sequence patterns along the double helix. These notes aim to introduce basic polymer physics of DNA molecules, biophysics of protein-DNA interactions and their study in single-DNA experiments, and some aspects of large-scale chromosome structure. Mechanisms for control of chromosome topology will also be discussed.

Indexed as

chromosome dynamicschromosome structureDNADNA-protein interactions

Identifiers

PMID25419039
PMCPMC4235750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.