Evidence map›Paper›PMID 25418982›Full record

ArticleNanoscale2015

Dual-radiolabeled nanoparticle SPECT probes for bioimaging.

Kvar C L Black, Walter J Akers, Gail Sudlow, Baogang Xu, Richard Laforest, Samuel Achilefu

Abstract read
In one paragraph

Article in Nanoscale, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Nanotheranostics: A Cutting-edge Technology for Cancer Management.Current pharmaceutical biotechnology · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Multiplexed imaging in oncology.Nature biomedical engineering · 2022
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Seeing Better and Going Deeper in Cancer Nanotheranostics.International journal of molecular sciences · 2019
    Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kvar C L BlackDepartment of Radiology, Washington University, St. Louis, Missouri 63110, USA.
Walter J Akers
Gail Sudlow
Baogang Xu
Richard Laforest
Samuel Achilefu

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU-MDACC Inter-Institutional Molecular Imaging CenterP50CA094056 · NCI · WASHINGTON UNIVERSITY · PI KOPAN, RAPHAEL · 2002 to 2016
$26.3M
DEVELOPMENT OF GOGGLE SYSTEM FOR FLUORESCENCE IMAGE-GUIDED SURGERYR01CA171651 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2013 to 2017
$2.8M
NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA094056NCI NIH HHS R01 CA171651
6 · The paper itself

Abstract

A gold nanoparticle was radiolabeled with (125)I and (111)In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.

Indexed as

Tomography, Emission-Computed, Single-PhotonAnimalsCell Line, TumorContrast MediaGoldHumansIndium RadioisotopesIodine RadioisotopesMatrix Metalloproteinase 9Metal NanoparticlesMiceTissue DistributionTransplantation, HeterologousContrast MediaGoldIndium RadioisotopesIodine RadioisotopesMatrix Metalloproteinase 9

Identifiers

PMID25418982
PMCPMC4268305

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.