Evidence map›Paper›PMID 25418741›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2015

Superparamagnetic iron oxide nanoparticle micelles stabilized by recombinant oleosin for targeted magnetic resonance imaging.

Kevin B Vargo, Ajlan Al Zaki, Robert Warden-Rothman, Andrew Tsourkas, Daniel A Hammer

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. High-Entropy Materials for Prospective Biomedical Applications: Challenges and Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kevin B VargoDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19103, USA.
Ajlan Al Zaki
Robert Warden-Rothman
Andrew Tsourkas
Daniel A Hammer

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
Simulation of Lymphocyte Adhesion using Integrated Adhesive DynamicsR01AI082292 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAMMER, DANIEL A · 2009 to 2017
$2.8M
Gold-Loaded Polymeric MicellesR21EB013754 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2012 to 2013
$436k
NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1RR024134NIAID NIH HHS R01 AI082292NIBIB NIH HHS R21 EB013754NIBIB NIH HHS R21EB013754
6 · The paper itself

Abstract

Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle-loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibody-oleosin fusion. The recombinant oleosin platform allows simple targeting and the ability to easily swap the ligand for numerous targets.

Indexed as

3T3 CellsAnimalsContrast MediaDextransErb-b2 Receptor Tyrosine KinasesExcipientsMagnetic Resonance ImagingMagnetite NanoparticlesMiceMicellesPlant ProteinsRecombinant ProteinsContrast MediaDextransERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesExcipientsferumoxtran-10Magnetite NanoparticlesMicellesPlant ProteinsRecombinant Proteinscontrast agentsiron oxideMRI contrastoleosinrecombinant surfactantstargeting

Identifiers

PMID25418741
PMCPMC4746475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.