Fractal globules: a new approach to artificial molecular machines.

Vladik A Avetisov, Viktor A Ivanov, Dmitry A Meshkov, Sergei K Nechaev

Abstract read

In one paragraph

Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Coarse-Grained Protein Dynamics Studies Using Elastic Network Models.International journal of molecular sciences · 2018
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vladik A AvetisovN. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia; Department of Applied Mathematics, National Research University Higher School of Economics, Moscow, Russia. Electronic address: vladik.avetisov@gmail.com.

Viktor A IvanovFaculty of Physics of the M. V. Lomonosov Moscow State University, Moscow, Russia.

Dmitry A MeshkovN. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.

Sergei K NechaevUniversité Paris-Sud/Centre National de la Recherche Scientifique, Laboratoire de Physique Theorique et Modèles Statistiques, Orsay, France; P. N. Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russia; Department of Applied Mathematics, National Research University Higher School of Economics, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The over-damped relaxation of elastic networks constructed by contact maps of hierarchically folded fractal (crumpled) polymer globules was investigated in detail. It was found that the relaxation dynamics of an anisotropic fractal globule is very similar to the behavior of biological molecular machines like motor proteins. When it is perturbed, the system quickly relaxes to a low-dimensional manifold, M, with a large basin of attraction and then slowly approaches equilibrium, not escaping M. Taking these properties into account, it is suggested that fractal globules, even those made by synthetic polymers, are artificial molecular machines that can transform perturbations into directed quasimechanical motion along a defined path.

Indexed as

BiomimeticsFractalsElasticityModels, MolecularMolecular ConformationMolecular Motor ProteinsPolymersMolecular Motor ProteinsPolymers

Identifiers

PMID25418305

DOI10.1016/j.bpj.2014.10.019

PMCPMC4241456

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.