ArticleBiophysical journal2014
Molecular determinants of mechanical properties of V. cholerae biofilms at the air-liquid interface.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
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- Geometric ordering in bacterial communities.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Microbiological and rheological dynamics of mixed biofilms formed by bacteria and eukaryotic virus.Scientific reports · 2026Article
- Genetic Insights into the Rheological Phenotype of Candida albicans Biofilms.Research square · 2026Article
- Antibacterial and Antibiofilm Activities of Bluestem (International journal of microbiology · 2026Article
- Thermodynamics of Surfactant-Enriched Binary-Fluid Systems.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Vibrio cholerae RbmB is an α-1,4-polysaccharide lyase with biofilm-disrupting activity against Vibrio polysaccharide (VPS).PLoS pathogens · 2024Article
- Article
- Microstructural and Rheological Transitions in Bacterial Biofilms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Quorum-sensing control of matrix protein production drives fractal wrinkling and interfacial localization of Vibrio cholerae pellicles.Nature communications · 2022Article
- Systems view of Bacillus subtilis pellicle development.NPJ biofilms and microbiomes · 2022Article
- Shear stress affects the architecture and cohesion of Chlorella vulgaris biofilms.Scientific reports · 2021Article
- Searching for the Secret of Stickiness: How Biofilms Adhere to Surfaces.Frontiers in microbiology · 2021Review
- Biophysical methods to quantify bacterial behaviors at oil-water interfaces.Journal of industrial microbiology & biotechnology · 2020Review
- AnApplied and environmental microbiology · 2020Article
- Metal ions weaken the hydrophobicity and antibiotic resistance ofNPJ biofilms and microbiomes · 2020Article
- The 1.9 Å crystal structure of the extracellular matrix protein Bap1 fromThe Journal of biological chemistry · 2019Article
- Regulating, Measuring, and Modeling the Viscoelasticity of Bacterial BiofilmsJournal of bacteriology · 2019Review
- The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix.Nature communications · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Biofilm formation increases both the survival and infectivity of Vibrio cholerae, the causative agent of cholera. V. cholerae is capable of forming biofilms on solid surfaces and at the air-liquid interface, termed pellicles. Known components of the extracellular matrix include the matrix proteins Bap1, RbmA, and RbmC, an exopolysaccharide termed Vibrio polysaccharide, and DNA. In this work, we examined a rugose strain of V. cholerae and its mutants unable to produce matrix proteins by interfacial rheology to compare the evolution of pellicle elasticity in real time to understand the molecular basis of matrix protein contributions to pellicle integrity and elasticity. Together with electron micrographs, visual inspection, and contact angle measurements of the pellicles, we defined distinct contributions of the matrix proteins to pellicle morphology, microscale architecture, and mechanical properties. Furthermore, we discovered that Bap1 is uniquely required for the maintenance of the mechanical strength of the pellicle over time and contributes to the hydrophobicity of the pellicle. Thus, Bap1 presents an important matrix component to target in the prevention and dispersal of V. cholerae biofilms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.