ArticleBiophysical journal2014
Direct measurements of drag forces in C. elegans crawling locomotion.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 60 citations in OpenAlex.
- Mechanosensory encoding of surface mechanics optimizes locomotion.Nature communications · 2026Article
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- Forces and symmetry breaking of a living meso-swimmer.Communications physics · 2026Article
- Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- A neuromechanical model for Drosophila larval crawling based on physical measurements.BMC biology · 2022Article
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- Modelling the mechanics of exploration in larval Drosophila.PLoS computational biology · 2019Article
- Physical exertion exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophy.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Micropipette force sensors for in vivo force measurements on single cells and multicellular microorganisms.Nature protocols · 2019Article
- From head to tail: a neuromechanical model of forward locomotion inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Three-dimensional simulation of thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans.Lab on a chip · 2018Article
- Durotaxis in Nematode Caenorhabditis elegans.Biophysical journal · 2016Article
- The nematode C. elegans as a complex viscoelastic fluid.The European physical journal. E, Soft matter · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With a simple and versatile microcantilever-based force measurement technique, we have probed the drag forces involved in Caenorhabditis elegans locomotion. As a worm crawls on an agar surface, we found that substrate viscoelasticity introduces nonlinearities in the force-velocity relationships, yielding nonconstant drag coefficients that are not captured by original resistive force theory. A major contributing factor to these nonlinearities is the formation of a shallow groove on the agar surface. We measured both the adhesion forces that cause the worm's body to settle into the agar and the resulting dynamics of groove formation. Furthermore, we quantified the locomotive forces produced by C. elegans undulatory motions on a wet viscoelastic agar surface. We show that an extension of resistive force theory is able to use the dynamics of a nematode's body shape along with the measured drag coefficients to predict the forces generated by a crawling nematode.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.