ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2015
Quantifying silicone oil emulsification in patients: are we only seeing the tip of the iceberg?
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Risk factors for early emulsification of silicone oil after surgery for rhegmatogenous retinal detachment.Indian journal of ophthalmology · 2026Observational
- Emulsification Complexity of Silicone Oil in Retinal Surgery: In Vitro Insights into Phase Behavior.ACS omega · 2026Article
- Incidence and risk factors of late-onset intraocular pressure elevation after vitrectomy with silicone oil tamponade.Japanese journal of ophthalmology · 2025Observational
- Anterior segment optical coherence tomography for the detection of silicone oil emulsification on the iris surface.Eye (London, England) · 2024Article
- The Role of Eye Movements in the Process of Silicone Oil Emulsification After Vitreoretinal Surgery.Bioengineering (Basel, Switzerland) · 2024Article
- Refinements in the use of silicone oil as an intraocular tamponade.Eye (London, England) · 2024Review
- Emulsification of Silicone Oils: Altering Factors and Possible Complications-A Narrative Review.Journal of clinical medicine · 2024Review
- Combining Perfluorobutylpentane (FTurkish journal of ophthalmology · 2023Article
- Silicone oil residual after vitrectomy for rhegmatogenous retinal detachment.Eye (London, England) · 2023Article
- Silicone Oil Tamponade Removal: Which Technique Is More Effective? An X-Ray Photoemission Spectroscopy Study.Translational vision science & technology · 2023Article
- Subepithelial white deposition in the cornea associated with silicone oil and surgical management: a case report.Frontiers in medicine · 2023Article
- Assessment of Silicone Oil Emulsification: A Comparison of Currently Applied Methods.Journal of ophthalmology · 2023Article
- Retinal and Corneal Changes Associated with Intraocular Silicone Oil Tamponade.Journal of clinical medicine · 2022Review
- What Is the Cause of Toxicity of Silicone Oil?Materials (Basel, Switzerland) · 2021Article
- Changes of macular vessel density and thickness in gas and silicone oil tamponades after vitrectomy for macula-on rhegmatogenous retinal detachment.BMC ophthalmology · 2021Article
- Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma.Progress in retinal and eye research · 2021Review
- Characteristics of Silicone Oil Emulsification After Vitrectomy for Rhegmatogenous Retinal Detachment: An Ultrasound Biomicroscopy Study.Frontiers in medicine · 2021Article
- Pars Plana Vitrectomy and the Risk of Ocular Hypertension and Glaucoma: Where Are We?Journal of clinical medicine · 2020Review
- Evaluation of emulsified silicone oil with spectral domain-optical coherence tomography and fluorescein angiography.International ophthalmology · 2020Article
- Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review.Vision (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEmulsification of silicone oil in the eye is a difficult problem. In an effort to find an objective way to quantify emulsification, we used the Coulter principle to measure silicone oil emulsified droplets from the washings of a series of patients.
methodsAqueous washouts after silicone oil removal were obtained from nine patients (nine eyes). We used the Coulter counter Multisizer® 4 to obtain the size distribution of the oil droplets.
resultsOver 65 % of the emulsified silicone oil droplets in the clinical samples had a diameter smaller than is detectable by light microscopy (2 μm). The median size of the droplets was between 1.1 and 1.9 μm. Based on the Spearman's correlation coefficient (r), there was a strong correlation between the number of the droplets that cannot be seen (between 1 and 2 μm) and those that can be seen (7-30 μm) (r = 0.817, p = 0.007).
conclusionOnce emulsification was detected clinically in the anterior chamber, extensive emulsification would have already occurred in the posterior chamber, with most of the emulsified droplets that were too small in size to be seen on clinical examination. Ostwald ripening might explain why there were so many small droplets. The predominance of small droplets might account for some of the clinical complications associated with silicone oil use.
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