ArticleThe New phytologist2015
Regulation of metabolic gene clusters in Arabidopsis thaliana.
Article in The New phytologist, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 60 citations in OpenAlex.
- Subfunctionalization and epigenetic regulation of a biosynthetic gene cluster inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Characterization of the Cannabis sativa glandular trichome epigenome.BMC plant biology · 2024Article
- Plant biosynthetic gene clusters in the context of metabolic evolution.Natural product reports · 2022Review
- BLISTER promotes seed maturation and fatty acid biosynthesis by interacting with WRINKLED1 to regulate chromatin dynamics in Arabidopsis.The Plant cell · 2022Article
- Ten decadal advances in fungal biology leading towards human well-being.Fungal diversity · 2022Review
- Phylogenomic and Microsynteny Analysis Provides Evidence of Genome Arrangements of High-Affinity Nitrate Transporter Gene Families of Plants.International journal of molecular sciences · 2021Article
- The emerging role of biosynthetic gene clusters in plant defense and plant interactions.PLoS pathogens · 2021Review
- Plant Metabolic Gene Clusters: Evolution, Organization, and Their Applications in Synthetic Biology.Frontiers in plant science · 2021Review
- Active and repressed biosynthetic gene clusters have spatially distinct chromosome states.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Co-Regulation of Clustered and Neo-Functionalized Genes in Plant-Specialized Metabolism.Plants (Basel, Switzerland) · 2020Review
- MYB57 transcriptionally regulates MAPK11 to interact with PAL2;3 and modulate rice allelopathy.Journal of experimental botany · 2020Article
- Gene Modules Co-regulated with Biosynthetic Gene Clusters for Allelopathy between Rice and Barnyardgrass.International journal of molecular sciences · 2019Article
- The genome of the medicinal plant Andrographis paniculata provides insight into the biosynthesis of the bioactive diterpenoid neoandrographolide.The Plant journal : for cell and molecular biology · 2019Article
- Bioinformatics tools for the identification of gene clusters that biosynthesize specialized metabolites.Briefings in bioinformatics · 2018Review
- H2A.Z promotes the transcription ofDevelopment (Cambridge, England) · 2018Article
- Developmental Plasticity of the Major Alkyl Cannabinoid Chemotypes in a DiverseFrontiers in plant science · 2018Article
- Genome-wide identification of physically clustered genes suggests chromatin-level co-regulation in male reproductive development in Arabidopsis thaliana.Nucleic acids research · 2017Article
- Nitrogen assimilation system in maize is regulated by developmental and tissue-specific mechanisms.Plant molecular biology · 2016Article
- Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways.Natural product reports · 2016Review
- Plant metabolic clusters - from genetics to genomics.The New phytologist · 2016Review
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2 authors at 2 institutions in 1 country.
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Abstract
Recent discoveries have revealed that the genes for the biosynthesis of a variety of plant specialized metabolites are organized in operon-like clusters within plant genomes. Here we identify a regulatory process that is required for normal expression of metabolic gene clusters in Arabidopsis thaliana. Comparative gene expression analysis of a representative clustered gene was performed in a set of chromatin mutant lines. Subsequently, metabolite levels were analysed by GC-MS and the local chromatin structure was investigated by chromatin immunoprecipitation and nucleosome positioning. We show that the transcript levels of genes within two metabolic clusters are coordinately reduced in an arp6 and h2a.z background. We demonstrate that H2A.Z enrichment in the clusters is positively correlated with active cluster expression. We further show that nucleosome stability within the cluster regions is higher in the arp6 background compared with the wild-type. These results implicate ARP6 and H2A.Z in the regulation of metabolic clusters in Arabidopsis thaliana through localized chromatin modifications that enable the coordinate expression of groups of contiguous genes. These findings shed light on the complex process of cluster regulation, an area that could in the future open up new opportunities for the discovery and manipulation of specialized metabolic pathways in plants.
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