ArticleJournal of veterinary internal medicine2015
Functional phenotype and its correlation with therapeutic response and inflammatory type of bronchoalveolar lavage fluid in feline lower airway disease.
Article in Journal of veterinary internal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Characterization of Brachycephalic Obstructive Airway Syndrome in Cats Using Barometric Whole-Body Plethysmography.Animals : an open access journal from MDPI · 2026Article
- Barometric whole-body plethysmography investigating breed-specific variations in dogs.Frontiers in veterinary science · 2026Article
- Alterations in tidal volume over recording time during pulmonary function testing by barometric whole-body plethysmography in client-owned cats: a multicenter retrospective investigation.BMC veterinary research · 2025Article
- Immune cell composition of the bronchoalveolar lavage fluid in healthy and respiratory diseased dromedary camels.BMC veterinary research · 2022Article
- Evaluation of barometric whole-body plethysmography for therapy monitoring in cats with feline lower airway disease.PloS one · 2022Article
- Treatment of naturally occurring asthma with inhaled fluticasone or oral prednisolone: A randomized pilot trial.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Article
- An observational study of the role of indoor air pollution in pets with naturally acquired bronchial/lung disease.Veterinary medicine and science · 2020Article
- Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011-2018).Journal of veterinary internal medicine · 2020Article
- Effect of transoral tracheal wash on respiratory mechanics in dogs with respiratory disease.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2018Article
- Simultaneous visual inspection for barometric whole-body plethysmography waveforms during pulmonary function testing in client-owned cats.Journal of feline medicine and surgery · 2016Article
- Influence of acclimatization time on barometric whole-body plethysmography in cats with lower airway disease.Journal of veterinary internal medicineArticle
- Assessing breathing effort by barometric whole-body plethysmography and its relationship with prognosis in client-owned cats with respiratory distress.Journal of veterinary internal medicineArticle
- Correlation of clinical and radiographic variables in cats with lower airway disease.Journal of veterinary internal medicineArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, functional assessment to monitor therapeutic response in feline lower airway disease (FLAD) has limited application.
objectivesTo evaluate if expiratory indices derived from pseudo-tidal breathing flow-volume loop (pTBFVL) representing lower airway obstruction would decrease after clinical improvement and to investigate the correlation between functional phenotype and inflammatory cell type in bronchoalveolar lavage (BAL) fluid. ANIMALS: Nineteen client-owned cats with FLAD.
methodsProspective observational study. Functional assessment with pTBFVL indices (eg, peak to mid-expiratory flow; PEF/EF50) and conventional barometric whole body plethysmography (BWBP) parameters (eg, enhanced pause) was carried out before receiving treatment. BAL was performed to analyze inflammatory cell types. Signs were assessed by scoring. The cats were treated with glucocorticoids daily and functional testing was repeated.
resultsLoop indices PEF/EF50 and PEF/EF25 were significantly decreased after treatment (P < .001). Conventional BWBP parameters were not significantly different before and after treatment. Cats with PEF/EF50 > 1.51 before treatment had a significantly higher granulocyte (eosinophil plus neutrophil) percentage in BAL fluid (P = .014). Granulocyte percentage in BAL fluid was strongly correlated with PEF/EF25 (P = .001, rs = 0.74) and moderately correlated with PEF/EF50 (P = .022, rs = 0.57), whereas eosinophil or neutrophil percentage alone had no significant correlation with functional parameters. CONCLUSIONS AND CLINICAL IMPORTANCE: Functional parameters including PEF/EF50 and PEF/EF25 can be used for monitoring therapeutic response. The presence of airflow limitation during mid- to late expiration is affected by the overall extent of granulocyte infiltration.
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