ArticleScientific reports2014
Heterogeneous red blood cell adhesion and deformability in sickle cell disease.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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Who cites it
65 citing papers in PubMed, 112 citations in OpenAlex.
- Impact of Red Blood Cell Deformability and Local Hematocrit on Microvascular Flow Resistance: Insights from In Vitro Microfluidic Measurements and Viscosity Modeling.Life (Basel, Switzerland) · 2026Article
- Sickle cell visualization in vivo in humans: microvascular occlusion formation and hemorheological indices.Blood advances · 2026Article
- Investigational New Drug-enabling studies in a human vessel-chip: Are we there yet?Bioengineering & translational medicine · 2026Review
- Comparative Evaluation of Two Image-Analysis Software Platforms for Microfluidic Assessment of Red Blood Cell Deformability in Chronic Lymphocytic Leukemia.Micromachines · 2026Article
- A Microfluidic Approach for Assessing the Rheological Properties of Healthy Versus Thalassemic Red Blood Cells.Micromachines · 2025Article
- Red Blood Cell-Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell-Depleted Thrombi, Restoring Severe Bacteremia in Rats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Partitioning of dense RBC suspensions in single microfluidic bifurcations: role of cell deformability and bifurcation angle.Scientific reports · 2024Article
- Physical mechanisms of red blood cell splenic filtration.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Biophysical Profiling of Sickle Cell Disease Using Holographic Cytometry and Deep Learning.International journal of molecular sciences · 2023Article
- Red blood cell distribution width is a risk factor for multiple organ dysfunction syndrome in elderly patients with infection: a case control study.Aging clinical and experimental research · 2023Article
- Catch bonds in sickle cell disease: Shear-enhanced adhesion of red blood cells to laminin.Biophysical journal · 2023Article
- The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness.International journal of molecular sciences · 2023Review
- A microfluidic device for assessment of E-selectin-mediated neutrophil recruitment to inflamed endothelium and prediction of therapeutic response in sickle cell disease.Biosensors & bioelectronics · 2023Article
- A preliminary study of phosphodiesterases and adenylyl cyclase signaling pathway on red blood cell deformability of sickle cell patients.Frontiers in physiology · 2023Article
- Hyperviscosity syndromes; hemorheology for physicians and the use of microfluidic devices.Current opinion in hematology · 2022Review
- Cardiovascular consequences of sickle cell disease.Biophysics reviews · 2022Review
- Microfluidic methods to advance mechanistic understanding and translational research in sickle cell disease.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Feature tracking microfluidic analysis reveals differential roles of viscosity and friction in sickle cell blood.Lab on a chip · 2022Article
- Proteomic Analysis of the Role of the Adenylyl Cyclase-cAMP Pathway in Red Blood Cell Mechanical Responses.Cells · 2022Article
- Single-cell analysis reveals chemokine-mediated differential regulation of monocyte mechanics.iScience · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a microfluidic approach that allows simultaneous interrogation of RBC properties in physiological flow conditions at a single cell level. With this method, we studied healthy hemoglobin A (HbA) and homozygous sickle hemoglobin (HbS) containing RBCs using whole blood samples from twelve subjects. We report that HbS-containing RBCs are heterogeneous in terms of adhesion and deformability in flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.