ArticleBreast cancer research and treatment2015
Confocal fluorescence microscopy for rapid evaluation of invasive tumor cellularity of inflammatory breast carcinoma core needle biopsies.
Article in Breast cancer research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Advanced Microscopy Techniques.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
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- [Fluorescence confocal microscopy-complete digitization of pathology].Pathologie (Heidelberg, Germany) · 2024Article
- Virtual Staining of Nonfixed Tissue Histology.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024Review
- Ultraviolet metasurface-assisted photoacoustic microscopy with great enhancement in DOF for fast histology imaging.Photoacoustics · 2023Article
- Optical coherence tomography holds promise to transform the diagnostic anatomic pathology gross evaluation process.Journal of biomedical optics · 2022Article
- Deep learning enables ultraviolet photoacoustic microscopy based histological imaging with near real-time virtual staining.Photoacoustics · 2022Article
- Is Real-Time Microscopy on the Horizon? A Brief Review of the Potential Future Directions in Clinical Breast Tumor Microscopy Implementation.Virchows Archiv : an international journal of pathology · 2022Review
- Deep learning extended depth-of-field microscope for fast and slide-free histology.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Raman Microscopy: Progress in Research on Cancer Cell Sensing.Sensors (Basel, Switzerland) · 2020Review
- Artifact-free whole-slide imaging with structured illumination microscopy and Bayesian image reconstruction.GigaScience · 2020Article
- Comparison of Real-Time Fluorescence Confocal Digital Microscopy With Hematoxylin-Eosin-Stained Sections of Core-Needle Biopsy Specimens.JAMA network open · 2020Article
- Comparative analysis of confocal microscopy on fresh breast core needle biopsies and conventional histology.Diagnostic pathology · 2019Article
- Digital staining through the application of deep neural networks to multi-modal multi-photon microscopy.Biomedical optics express · 2019Article
- Types of advanced optical microscopy techniques for breast cancer research: a review.Lasers in medical science · 2018Review
- 3D Imaging Detection of HER2 Based in the Use of Novel Affibody-Quantum Dots Probes and Ratiometric Analysis.Translational oncology · 2018Article
- Advances in the use of reflectance confocal microscopy in melanoma.Melanoma management · 2018Review
- Multiscale nonlinear microscopy and widefield white light imaging enables rapid histological imaging of surgical specimen margins.Biomedical optics express · 2018Article
- Rapid histopathological imaging of skin and breast cancer surgical specimens using immersion microscopy with ultraviolet surface excitation.Scientific reports · 2018Article
- International Consensus on the Clinical Management of Inflammatory Breast Cancer from the Morgan Welch Inflammatory Breast Cancer Research Program 10th Anniversary Conference.Journal of Cancer · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Tissue sampling is a problematic issue for inflammatory breast carcinoma, and immediate evaluation following core needle biopsy is needed to evaluate specimen adequacy. We sought to determine if confocal fluorescence microscopy provides sufficient resolution to evaluate specimen adequacy by comparing invasive tumor cellularity estimated from standard histologic images to invasive tumor cellularity estimated from confocal images of breast core needle biopsy specimens. Grayscale confocal fluorescence images of breast core needle biopsy specimens were acquired following proflavine application. A breast-dedicated pathologist evaluated invasive tumor cellularity in histologic images with hematoxylin and eosin staining and in grayscale and false-colored confocal images of cores. Agreement between cellularity estimates was quantified using a kappa coefficient. 23 cores from 23 patients with suspected inflammatory breast carcinoma were imaged. Confocal images were acquired in an average of less than 2 min per core. Invasive tumor cellularity estimated from histologic and grayscale confocal images showed moderate agreement by kappa coefficient: κ = 0.48 ± 0.09 (p < 0.001). Grayscale confocal images require less than 2 min for acquisition and allow for evaluation of invasive tumor cellularity in breast core needle biopsy specimens with moderate agreement to histologic images. We show that confocal fluorescence microscopy can be performed immediately following specimen acquisition and could indicate the need for additional biopsies at the initial visit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.