Evidence map›Paper›PMID 25417146›Full record

ArticleCell2014

Geroscience: linking aging to chronic disease.

Brian K Kennedy, Shelley L Berger, Anne Brunet, Judith Campisi, Ana Maria Cuervo, Elissa S Epel, Claudio Franceschi, Gordon J Lithgow, Richard I Morimoto, Jeffrey E Pessin and 5 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,578 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,578citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03707652 nacompletednot on this mapstarted 2018, after this paper: background citation

Three-Day Dosing NAD + Study

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2018 to 2018Enrolled8ConditionsIncrease in Blood Levels of Nicotinamide Adenine Dinucleotide (NAD+)ArmsOral supplement A, Oral supplement B, Oral supplement C, Oral supplement D, Oral Supplement D in combination with oral supplement C
NCT05732935 nacompletednot on this mapstarted 2023, after this paper: background citation

Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement (FASTING ENHANCE)

TypeinterventionalSponsorUniversity of FloridaRan2023 to 2026Enrolled45ConditionsOverweight and Obesity, Time Restricted Feeding, Alzheimer DiseaseArmsTime Restricted Eating intervention, Successful Aging Comparison Group (LEARN)
3 · Its place in the literature

Who cites it

1,578 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Interventions that prolong multidimensional healthspan in humans: a systematic review of randomized controlled trials.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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1,518 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Brian K KennedyBuck Institute for Research on Aging, Novato, CA USA. Electronic address: bkennedy@buckinstitute.org.
Shelley L BergerPenn Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology and Department of Genetics and Department of Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA 94305, USA; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA.
Judith CampisiBuck Institute for Research on Aging, Novato, CA USA; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Ana Maria CuervoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Elissa S EpelDepartment of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA.
Claudio FranceschiIRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy; C.I.G., Interdepartmental Center 'L. Galvani' for Integrated Studies on Bioinformatics, Biophysics, and Biocomplexity, University of Bologna, 3 Bologna, Italy; DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 3 Bologna, Italy.
Gordon J LithgowBuck Institute for Research on Aging, Novato, CA USA.
Richard I MorimotoDepartment of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.
Jeffrey E PessinDepartment of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Thomas A RandoGlenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Arlan RichardsonDonald W Reynolds Endowed Chair of Aging Research, Professor of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA; Oklahoma City VA Medical Center, Oklahoma City, OK 73104, USA.
Eric E SchadtIcahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences and the Icahn Institute for Genomics and Multiscale Biology, New York, NY 10029, USA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Felipe SierraDivision of Aging Biology, National Institute on Aging, Bethesda, MD 20892, USA.

Funding

Role of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MACIAN, FERNANDO · 2009 to 2024
$36.2M
Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARGARET A. GOODELL · 2011 to 2026
$29.3M
Nuclear Lamin Functions and Human DiseaseR01AG024287 · NIA · UNIVERSITY OF WASHINGTON · PI KENNEDY, BRIAN K · 2004 to 2013
$3.0M
System approaches to determine mechanisms underlying yeast replicative agingR01AG043080 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI KENNEDY, BRIAN K · 2012 to 2016
$3.0M
TOR, Translation and AgingR01AG033373 · NIA · UNIVERSITY OF WASHINGTON · PI KENNEDY, BRIAN K · 2009 to 2013
$1.8M
NIA NIH HHS P01 AG031782NIA NIH HHS P01 AG036695NIA NIH HHS R01 AG024287NIA NIH HHS R01 AG033373NIA NIH HHS R01 AG043080
6 · The paper itself

Abstract

Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.

Indexed as

Chronic DiseaseAgingAnimalsBiomedical ResearchEpigenesis, GeneticGene-Environment InteractionHumans

Identifiers

PMID25417146
PMCPMC4852871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.