Evidence map›Paper›PMID 25417106›Full record

ArticleCell2014

Enhancer interaction networks as a means for singular olfactory receptor expression.

Eirene Markenscoff-Papadimitriou, William E Allen, Bradley M Colquitt, Tracie Goh, Karl K Murphy, Kevin Monahan, Colleen P Mosley, Nadav Ahituv, Stavros Lomvardas

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 225 citations in OpenAlex.

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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Eirene Markenscoff-PapadimitriouNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
William E AllenNeuroscience Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bradley M ColquittNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Tracie GohDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
Karl K MurphyDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94158, USA.
Kevin MonahanDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
Colleen P MosleyDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
Nadav AhituvDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94158, USA.
Stavros LomvardasNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: sl682@columbia.edu.
University of California, San Francisco · USStanford University · US

Funding

VIRUS-INDUCED STRUCTURAL ALTERATIONS OF NUCLEUSP41RR019664 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOMVARDAS, STAVROS · 2004 to 2011
$8.2M
User Training and OutreachP30GM138441 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARABELL, CAROLYN A · 2020 to 2023
$3.7M
Devising New Technologies for Live Imaging of Epigenetic ProcessesR01DA030320 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARABELL, CAROLYN A, LOMVARDAS, STAVROS · 2010 to 2014
$2.3M
Characterization of regulatory elements leading to human limb malformationsR01HD059862 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, BEJERANO, GILL · 2009 to 2013
$2.2M
Influence of drug abuse on neuronal nuclear and chromatin architectureR01DA036985 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASBAUM, ALLAN I. · 2013 to 2016
$1.8M
Understanding the Role of Nuclear Architecture in Olfactory Receptor ChoiceR01DC013560 · NIDCD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOMVARDAS, STAVROS · 2014 to 2018
$1.7M
Identification & functional characterization of SIM1 obesity-associated variantsR01DK090382 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, VAISSE, CHRISTIAN · 2012 to 2015
$1.3M
Characterization of neuronal gene regulatory elements associated with epilepsyR01NS079231 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV · 2012 to 2015
$1.2M
Controlling epigenetic states and nuclear architecture in the brainR01DA036894 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARNEA, GILAD, LOMVARDAS, STAVROS · 2013 to 2017
$1.2M
NCRR NIH HHS P41 RR019664NICHD NIH HHS R01 HD059862NICHD NIH HHS R01HD059862NIDA NIH HHS 5R01DA030320NIDA NIH HHS 5R01DA036894NIDA NIH HHS R01 DA030320NIDA NIH HHS R01 DA036894NIDA NIH HHS R01 DA036985NIDCD NIH HHS 5R01DC013560NIDCD NIH HHS R01 DC013560NIDDK NIH HHS 1R01DK090382NIDDK NIH HHS R01 DK090382NIGMS NIH HHS P30 GM138441NINDS NIH HHS 1R01NS079231NINDS NIH HHS R01 NS079231
6 · The paper itself

Abstract

The transcriptional activation of one out of ?2800 olfactory receptor (OR) alleles is a poorly understood process. Here, we identify a plethora of putative OR enhancers and study their in vivo activity in olfactory neurons. Distinguished by an unusual epigenetic signature, candidate OR enhancers are characterized by extensive interchromosomal interactions associated with OR transcription and share a similar pattern of transcription factor footprints. In particular, we establish the role of the transcription factor Bptf as a facilitator of both enhancer interactions and OR transcription. Our observations agree with the model whereby OR transcription occurs in the context of multiple interacting enhancers. Disruption of these interchromosomal interactions results in weak and multigenic OR expression, suggesting that the rare coincidence of numerous enhancers over a stochastically chosen OR may account for the singularity and robustness in OR transcription.

Indexed as

Enhancer Elements, GeneticTranscriptional ActivationAnimalsAnimals, Genetically ModifiedAntigens, NuclearBromodomain Containing ProteinsMiceNerve Tissue ProteinsNucleoproteinsOlfactory Receptor NeuronsReceptors, OdorantTranscription FactorsZebrafishAntigens, NuclearBromodomain Containing Proteinsfetal Alzheimer antigenNerve Tissue ProteinsNucleoproteinsReceptors, OdorantTranscription Factors

Identifiers

PMID25417106
PMCPMC4243057
OpenAlexW1970956961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.