Evidence map›Paper›PMID 25416925›Full record

Trial reportItalian journal of pediatrics2014

Resveratrol plus carboxymethyl-β-glucan in children with recurrent respiratory infections: a preliminary and real-life experience.

Alfonso Maria Varricchio, Michele Capasso, Antonio Della Volpe, Luigi Malafronte, Nicola Mansi, Attilio Varricchio, Giorgio Ciprandi

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Italian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alfonso Maria VarricchioAssociazione Italiana Vie Aeree (AIVAS): Study Group on Respiratory Infections, Via P. Boselli 5, 16146, Genoa, Italy. alfonso.varricchio@gmail.com.
Michele CapassoAssociazione Italiana Vie Aeree (AIVAS): Study Group on Respiratory Infections, Via P. Boselli 5, 16146, Genoa, Italy. mic.capasso@gmail.com.
Antonio Della VolpeAssociazione Italiana Vie Aeree (AIVAS): Study Group on Respiratory Infections, Via P. Boselli 5, 16146, Genoa, Italy. antonio.dellavolpe@gmail.com.
Luigi MalafronteAssociazione Italiana Vie Aeree (AIVAS): Study Group on Respiratory Infections, Via P. Boselli 5, 16146, Genoa, Italy. luigi.malafronte@gmail.com.
Nicola MansiAssociazione Italiana Vie Aeree (AIVAS): Study Group on Respiratory Infections, Via P. Boselli 5, 16146, Genoa, Italy. nicola.mansi@libero.it.
Attilio VarricchioAssociazione Italiana Vie Aeree (AIVAS): Study Group on Respiratory Infections, Via P. Boselli 5, 16146, Genoa, Italy. attilio.varricchio@aivas.it.
Giorgio CiprandiAssociazione Italiana Vie Aeree (AIVAS): Study Group on Respiratory Infections, Via P. Boselli 5, 16146, Genoa, Italy. gio.cip@libero.it.
Associazione Italiana Di Oncologia Medica · ITAssociazione Italiana Arbitri · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecurrent respiratory infections (RRI), such as the presence of at least one of the following criteria: i) >6 RI per year; ii) >1 RI per month involving upper airways from September to April; iii) >3 RI involving lower airways, constitute a social problem for both their pharmaco-economic impact and the burden for the family. However, several treatment have been proposed with controversial results.

objectiveAs resveratrol plus carboxymethyl-β-glucan is presently available as solution for aerosol, the aim of this study was to evaluate the effects of this compound, compared to saline solution, whether it is able to prevent RRI in children.

designThe study was designed as real-life, randomized. Globally, 82 children (49 males, mean age 8.1 ± 2.6 years) with acute rhinopharyngitis and RRI were enrolled. Resveratrol plus carboxymethyl-β-glucan or saline isotonic solution was randomly (ratio 1:1) administered immediately after an anti-infective and anti-inflammatory 10-day treatment (tiamphenicol associated with acetylcysteine plus beclomethasone dipropionate) for the acute rhinopharyngitis. Investigated treatments lasted 20 days. Days with respiratory symptoms, fever, medication use, medical visits, and school absences were evaluated. Children were visited 30, 60, and 90 days after starting treatments.

resultsThe active compound was able to significantly reduce the number of days with nasal obstruction (p < 0.001), rhinorrhea (p < 0.001), sneezing (p < 0.001), cough (p = 0.002), fever (p < 0.001), medication use (p < 0.001), medical visits (p < 0.001), and school absence (p < 0.001).

conclusionsThis preliminary and real-life study could suggest that an aerosolized solution containing resveratrol plus carboxymethyl-β-glucan might exert preventive effects in children with RRI.

Indexed as

Anti-Inflammatory Agents, Non-Steroidalbeta-GlucansChildCytarabineDrug Therapy, CombinationFemaleFollow-Up StudiesHumansLife Change EventsMaleRecurrenceRespiratory Tract InfectionsResveratrolStilbenesTreatment OutcomeVasodilator AgentsAnti-Inflammatory Agents, Non-Steroidalbeta-Glucanscarboxymethyl-beta-glucan-cytarabineCytarabineResveratrolStilbenesVasodilator Agents

Identifiers

PMID25416925
PMCPMC4245789
OpenAlexW2148937202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.