ArticleThe Journal of infectious diseases2015
Influenza vaccine effectiveness in households with children during the 2012-2013 season: assessments of prior vaccination and serologic susceptibility.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Does repeated influenza vaccination attenuate effectiveness? A systematic review and meta-analysis.The Lancet. Respiratory medicine · 2023Pooled it
- The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis.BMC medicine · 2019Pooled it
- The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis.BMC medicine · 2017Pooled it
- Antibody response to sequential vaccination with cell culture, recombinant, or egg-based influenza vaccines among U.S. adults.Human vaccines & immunotherapeutics · 2024Trial
- Immunogenicity of AS03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults: A Phase 3, randomized trial and post-hoc correlate of protection analysis.Human vaccines & immunotherapeutics · 2016Trial
- Influenza vaccination of pregnant women protects them over two consecutive influenza seasons in a randomized controlled trial.Expert review of vaccines · 2016Trial
- Effect of Previous-Year Vaccination on the Efficacy, Immunogenicity, and Safety of High-Dose Inactivated Influenza Vaccine in Older Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Trial
- Persistence of Antibodies to Influenza Hemagglutinin and Neuraminidase Following One or Two Years of Influenza Vaccination.The Journal of infectious diseases · 2015Trial
- The Dual Role of Preexisting Immunity in Influenza: Protective Recall Versus Constraint of Novel Responses.Immunological reviews · 2026Review
- Poor sleep impairs immune responses and influenza vaccine protection.Nature communications · 2026Article
- A Comparative Profile of the Burden of Human Metapneumovirus, Respiratory Syncytial Virus, and Influenza in the HIVE Cohort, 2010-2022.The Journal of infectious diseases · 2025Article
- Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?The Journal of experimental medicine · 2025Review
- Article
- The impact of repeated vaccination on relative influenza vaccine effectiveness among vaccinated adults in the United Kingdom.Epidemiology and infection · 2022Article
- Influence of Prior Influenza Vaccination on Current Influenza Vaccine Effectiveness in Children Aged 1 to 5 Years.Vaccines · 2021Article
- Effectiveness of Influenza Vaccines in the HIVE Household Cohort Over 8 Years: Is There Evidence of Indirect Protection?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Simple models to include influenza vaccination history when evaluating the effect of influenza vaccination.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021Article
- The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination.Vaccines · 2020Article
- [High-dose trivalent influenza vaccine. Efficacy and effectiveness].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2020Review
- Influenza in the school-aged population in Mexico: burden of disease and cost-effectiveness of vaccination in children.BMC infectious diseases · 2020Article
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Funding
Abstract
backgroundThere are recognized needs to identify determinants of influenza vaccine effectiveness (VE), including the effect of repeated annual vaccination.
methodsWe recruited 321 households with 1426 members, including 833 children, and followed them during the 2012-2013 influenza season; specimens were collected from subjects with reported acute respiratory illnesses. We estimated the effectiveness of documented influenza vaccination in preventing laboratory-confirmed influenza, using adjusted Cox proportional hazards models. Antibody titers in a subset of subjects were determined by a hemagglutination inhibition assay to determine the subjects' preseason susceptibility to influenza.
resultsInfluenza was identified in 76 (24%) households and 111 (8%) individuals. VE point estimates indicated significant protection in adults (48%; 95% confidence interval [CI], 1%-72%), similar protection in children aged 9-17 years (49%; 95% CI, -16% to 78%), but no evidence of effectiveness in children aged <9 years (-4%; 95% CI, -110% to 49%). Lower VE was observed in those vaccinated in both the current and prior seasons, compared with those vaccinated in the current season only; susceptibility titers against type A but not type B were consistent with this observation. Residual protection from vaccination in the prior season was indicated by both VE and serologic results.
conclusionsPrior vaccination appears to modify VE by both residual protection and reduced vaccine response.
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