Evidence map›Paper›PMID 25416803›Full record

ArticleNucleic acids research2015

DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions.

Ioannis S Vlachos, Maria D Paraskevopoulou, Dimitra Karagkouni, Georgios Georgakilas, Thanasis Vergoulis, Ilias Kanellos, Ioannis-Laertis Anastasopoulos, Sofia Maniou, Konstantina Karathanou, Despina Kalfakakou and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 458 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
458citing papers in PubMed, 2 pooled it
26.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

458 citing papers in PubMed, 2 syntheses or guidelines pooled it, 804 citations in OpenAlex.

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398 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Ioannis S VlachosDIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece Laboratory for Experimental Surgery and Surgical Research 'N.S. Christeas', Medical School of Athens, University of Athens, 11527 Athens, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.
Maria D ParaskevopoulouDIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
Dimitra KaragkouniDIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
Georgios GeorgakilasDIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
Thanasis Vergoulis'Athena' Research and Innovation Center, 11524 Athens, Greece.
Ilias Kanellos'Athena' Research and Innovation Center, 11524 Athens, Greece School of Electrical and Computer Engineering, NTUA, 15773 Zografou, Greece.
Ioannis-Laertis AnastasopoulosDepartment of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
Sofia ManiouDepartment of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
Konstantina KarathanouDepartment of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
Despina KalfakakouDepartment of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
Athanasios FevgasDepartment of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
Theodore Dalamagas'Athena' Research and Innovation Center, 11524 Athens, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.
Artemis G HatzigeorgiouDIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.
National and Kapodistrian University of Athens · GRUniversity of Thessaly · GRAthena Research and Innovation Center In Information Communication & Knowledge Technologies · GRNational Technical University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene expression regulators. Accurate identification of miRNA targets is crucial to understanding their function. Currently, hundreds of thousands of miRNA:gene interactions have been experimentally identified. However, this wealth of information is fragmented and hidden in thousands of manuscripts and raw next-generation sequencing data sets. DIANA-TarBase was initially released in 2006 and it was the first database aiming to catalog published experimentally validated miRNA:gene interactions. DIANA-TarBase v7.0 (http://www.microrna.gr/tarbase) aims to provide for the first time hundreds of thousands of high-quality manually curated experimentally validated miRNA:gene interactions, enhanced with detailed meta-data. DIANA-TarBase v7.0 enables users to easily identify positive or negative experimental results, the utilized experimental methodology, experimental conditions including cell/tissue type and treatment. The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments. More than half a million miRNA:gene interactions have been curated from published experiments on 356 different cell types from 24 species, corresponding to 9- to 250-fold more entries than any other relevant database. DIANA-TarBase v7.0 is freely available.

Indexed as

Databases, Nucleic AcidAbstracting and IndexingBinding SitesData MiningInternetMicroRNAsRNA, MessengerUser-Computer InterfaceMicroRNAsRNA, Messenger

Identifiers

PMID25416803
PMCPMC4383989
OpenAlexW2133658633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.