ArticleApplied and environmental microbiology2015
Novel variant serotype of streptococcus suis isolated from piglets with meningitis.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed.
- Streptococcus suis in Asia: epidemiology, transmission and zoonotic risk at the animal-human interface.Veterinary research communications · 2026Review
- Population Genetic Architecture of theVeterinary sciences · 2026Article
- Identification and Evaluation of Conserved Subunit Vaccine Candidates Conferring Cross-Serotype Protection AgainstTransboundary and emerging diseases · 2026Article
- Genomic re-evaluation of clinical isolates reveals a structuredJournal of clinical microbiology · 2025Article
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- Serotype distribution and antimicrobial susceptibility of Streptococcus suis isolates from porcine diagnostic samples in Hungary, 2020-2023.Porcine health management · 2025Article
- Epidemiological investigation and pathogenicity ofFrontiers in microbiology · 2025Article
- Article
- Streptococcal arginine deiminase system defences macrophage bactericidal effect mediated by XRE family protein XtrSs.Virulence · 2024Article
- Article
- A multi-epitope subunit vaccine providing broad cross-protection against diverse serotypes of Streptococcus suis.NPJ vaccines · 2024Article
- Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe.Veterinary research · 2024Article
- Whole genome sequence and characterisation of Streptococcus suis 3112, isolated from snakeskin gourami, Trichopodus pectoralis.BMC genomics · 2024Article
- Insight into the role of Streptococcus suis zinc metalloprotease C from the new serotype causing meningitis in piglets.BMC veterinary research · 2024Article
- Genomic epidemiology inHeliyon · 2024Review
- Virulence genes, resistome and mobilome ofMicrobial genomics · 2024Article
- Comparative Genome Analysis of TwoAnimals : an open access journal from MDPI · 2024Article
- Combined Immunoinformatics to Design and Evaluate a Multi-Epitope Vaccine Candidate againstVaccines · 2024Article
- Detection and disease diagnosis trends (2017-2022) for Streptococcus suis, Glaesserella parasuis, Mycoplasma hyorhinis, Actinobacillus suis and Mycoplasma hyosynoviae at Iowa State University Veterinary Diagnostic Laboratory.BMC veterinary research · 2023Article
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7 authors.
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Abstract
Streptococcus suis is an emerging zoonotic pathogen causing severe infections in pigs and humans. In previous studies, 33 serotypes of S. suis have been identified using serum agglutination. Here, we describe a novel S. suis strain, CZ130302, isolated from an outbreak of acute piglet meningitis in eastern China. Strong pathogenicity of meningitis caused by strain CZ130302 was reproduced in the BALB/c mouse model. The strain showed a high fatality rate (8/10), higher than those for known virulent serotype 2 strains P1/7 (1/10) and 9801 (2/10). Cell adhesion assay results with bEnd.3 and HEp2 cells showed that CZ130302 was significantly close to P1/7 and 9801. Both the agglutination test and its complementary test showed that strain CZ130302 had no strong cross-reaction with the other 33 S. suis serotypes. The multiplex PCR assays revealed no specified bands for all four sets used to detect the other 33 serotypes. In addition, genetic analysis of the whole cps gene clusters of all serotypes was performed in this study. The results of comparative genomics showed that the cps gene cluster of CZ130302, which was not previously reported, showed no homology to the gene sequences of the other strains. Especially, the wzy, wzx, and acetyltransferase genes of strain CZ130302 are phylogenetically distinct from strains of the other 33 serotypes. Therefore, this study suggested that strain CZ130302 represents a novel variant serotype of S. suis (designated serotype Chz) which has a high potential to be virulent and associated with meningitis in animals.
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