ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015
Depressive symptoms and short telomere length are associated with increased mortality in bladder cancer patients.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 6 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Intensive nursing interventions for post-treatment anxiety and depression in bladder cancer: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Systematic review of associations between anxiety, depression, and functional/biological aging among cancer survivors.JNCI cancer spectrum · 2024Pooled it
- Pooled it
- Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies.Molecular psychiatry · 2020Pooled it
- Association between telomere length and survival in cancer patients: a meta-analysis and review of literature.Frontiers of medicine · 2016Pooled it
- The Association between Telomere Length and Cancer Prognosis: Evidence from a Meta-Analysis.PloS one · 2015Pooled it
- Coping in Patients With Incurable Lung and Gastrointestinal Cancers: A Validation Study of the Brief COPE.Journal of pain and symptom management · 2017Trial
- The Notable Role of Telomere Length Maintenance in Complex Diseases.Biomedicines · 2024Review
- Role of telomere length in human carcinogenesis (Review).International journal of oncology · 2023Review
- Long-term ozone exposure is positively associated with telomere length in critically ill patients.Environment international · 2020Observational
- Chronic Unpredictable Mild Stress Accelerates the Growth of Bladder Cancer in a Xenograft Mouse Model.Psychology research and behavior management · 2020Article
- Systematic Review: Depression and Anxiety Prevalence in Bladder Cancer Patients.Bladder cancer (Amsterdam, Netherlands) · 2018Article
- Telomere Length and Lung Cancer Mortality among Heavy Smokers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Association analysis of telomere length related gene ACYP2 with the gastric cancer risk in the northwest Chinese Han population.Oncotarget · 2017Article
- Psychiatric Disorders, Morbidity, and Mortality: Tracing Mechanistic Pathways to Accelerated Aging.Psychosomatic medicine · 2016Article
- Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report.Molecular neuropsychiatry · 2016Article
- Psychological Profiles in the Prediction of Leukocyte Telomere Length in Healthy Individuals.PloS one · 2016Article
- Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.Neuroscience and biobehavioral reviews · 2015Review
- Depressive symptoms and shorter survival in lung cancer: the role of leukocyte telomere length.Psychology & healthArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDepression is associated with an increased risk of mortality in patients with cancer; it has been hypothesized that depression-associated alterations in cell aging mechanisms, in particular, the telomere/telomerase maintenance system, may underlie this increased risk. We evaluated the association of depressive symptoms and telomere length to mortality and recurrence/progression in 464 patients with bladder cancer.
methodsWe used the Center for Epidemiologic Studies Depression Scale (CES-D) and Structured Clinical Interview for DSM-IV Disorder (SCID) to assess current depressive symptoms and lifetime major depressive disorder (MDD), respectively, and telomere length was assessed from peripheral blood lymphocytes. Multivariate Cox regression was used to assess the association of depression and telomere length to outcomes and the joint effect of both. Kaplan-Meier plots and log-rank tests were used to compare survival time of subgroups by depression variables and telomere length.
resultsPatients with depressive symptoms (CES-D ≥ 16) had a 1.83-fold [95% confidence interval (CI), 1.08-3.08; P = 0.024] increased risk of mortality compared with patients without depressive symptoms (CES-D < 16) and shorter disease-free survival time (P = 0.004). Patients with both depressive symptoms and lifetime history of MDD were at 4.88-fold (95% CI, 1.40-16.99; P = 0.013) increased risk compared with patients with neither condition. Compared to patients without depressive symptoms and long telomere length, patients with depressive symptoms and short telomeres exhibited a 4-fold increased risk of mortality (HR, 3.96; 95% CI, 1.86-8.41; P = 0.0003) and significantly shorter disease-free survival time (P < 0.001).
conclusionShort telomere length and depressive symptoms are associated with bladder cancer mortality individually and jointly. IMPACT: Further investigation of interventions that impact depression and telomere length may be warranted in patients with cancer.
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