SynthesisBMC nephrology2014
Long-term risk of chronic kidney disease and mortality in children after acute kidney injury: a systematic review.
Synthesis in BMC nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
92 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pediatric rhabdomyolysis: a systematic review and meta-analysis of etiologies, management, and outcomes.BMC pediatrics · 2025Pooled it
- Eculizumab in Shiga toxin-producing Escherichia coli hemolytic uremic syndrome: a systematic review.Pediatric nephrology (Berlin, Germany) · 2024Pooled it
- Pooled it
- Pregnancy outcomes in patients with acute kidney injury during pregnancy: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2017Pooled it
- Neonatal acute kidney injury: Reassessing diagnostic criteria for acute kidney injury in neonates with hypoxic-ischaemic encephalopathy undergoing therapeutic hypothermia.Pediatric nephrology (Berlin, Germany) · 2026Article
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- TIMP-2 and IGFBP7 for the differentiation of functional and intrinsic pediatric acute kidney injury.Pediatric research · 2026Article
- Acute kidney injury during treatment of pediatric brain tumors: a retrospective analysis of survivors.Pediatric research · 2026Article
- Using health systems evidence to study and predict long-term outcomes of childhood acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2026Article
- Understanding the Impact of Patent Ductus Arteriosus and Treatment Strategies on Acute Kidney Injury in Preterm Infants.American journal of perinatology · 2026Review
- Kidney health in VACTERL association: structural vulnerability and surveillance.Childhood kidney diseases · 2026Article
- Incidence and severity of extrarenal manifestations and outcomes in pediatric hemolytic uremic syndrome: a retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Pediatric acute kidney injury: what do we know about etiology and recovery?Childhood kidney diseases · 2026Article
- Risk Factors and Outcomes of Acute Kidney Injury in Children With Congenital Heart Disease Following Cardiac Surgery.Saudi medical journal · 2026Article
- Interpretable machine learning for the early prediction of acute kidney injury in preterm infants in the neonatal intensive care unit.Renal failure · 2025Article
- Article
- Progression of acute kidney injury to chronic kidney disease: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Quantifying "Medical Renal Disease": A Pediatric Pilot Study Using Ultrasound Radiomics for Differentiating Acute Kidney Injury and Chronic Kidney Disease.Diagnostics (Basel, Switzerland) · 2025Article
- Risk factors for adverse short-term and long-term outcomes in children with severe acute kidney injury requiring continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2025Article
- Machine learning model for the prediction of postoperative acute kidney injury (AKI) in neonates undergoing digestive surgery.Pediatric surgery international · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundAcute kidney injury (AKI) is associated with significant short-term morbidity and mortality in children. However, the risk for long-term outcomes after AKI is largely unknown.
methodsWe performed a systematic review and meta-analysis to determine the cumulative incidence rate of proteinuria, hypertension, decline in glomerular filtration rate (GFR), and mortality after an episode of AKI. After screening 1934 published articles from 1985-2013, we included 10 cohort studies that reported long-term outcomes after AKI in children.
resultsA total of 346 patients were included in these studies with a mean follow-up of 6.5 years (range 2-16) after AKI. The studies were of variable quality and had differing definitions of AKI with five studies only including patients who required dialysis during an AKI episode. There was a substantial discrepancy in the outcomes across these studies, most likely due to study size, disparate outcome definitions, and methodological differences. In addition, there was no non-AKI comparator group in any of the published studies. The cumulative incidence rates for proteinuria, hypertension, abnormal GFR (<90 ml/min/1.73 m2), GFR < 60 ml/min/1.73 m2, end stage renal disease, and mortality per 100 patient-years were 3.1 (95% CI 2.1-4.1), 1.4 (0.9-2.1), 6.3 (5.1-7.5), 0.8 (0.4 -1.4), 0.9 (0.6-1.4), and 3.7 (2.8-4.5) respectively.
conclusionsAKI appears to be associated with a high risk of long-term renal outcomes in children. These findings may have implications for care after an episode of AKI in children. Future prospective studies with appropriate non-AKI comparator groups will be required to confirm these results.
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