ArticlePlant physiology2015
In planta processing and glycosylation of a nematode CLAVATA3/ENDOSPERM SURROUNDING REGION-like effector and its interaction with a host CLAVATA2-like receptor to promote parasitism.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 66 citations in OpenAlex.
- A natural variation in rice susceptibility factor Rsf1 confers resistance to root-knot nematode.Nature communications · 2026Article
- Molecular mimicry and trafficking of peptide effectors in sedentary nematodes: emerging drivers of feeding site formation and host signaling hijack.Crop health · 2026Review
- A major role of class III HD-ZIPs in promoting sugar beet cyst nematode parasitism in Arabidopsis.PLoS pathogens · 2024Article
- CLE peptide signaling in plant-microbe interactions.Frontiers in plant science · 2024Review
- Pathogen-triggered changes in plant development: Virulence strategies or host defense mechanism?Frontiers in microbiology · 2023Review
- Characterization and response of two potato receptor-like kinases to cyst nematode infection.Plant signaling & behavior · 2022Article
- A plant cell wall-associated kinase encoding gene is dramatically downregulated during nematode infection of potato.Plant signaling & behavior · 2022Article
- Plant immunity: Rice XA21-mediated resistance to bacterial infection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dialog between Kingdoms: Enemies, Allies and Peptide Phytohormones.Plants (Basel, Switzerland) · 2021Review
- The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes.Nature communications · 2021Article
- Potato cyst nematodes Globodera rostochiensis and G. pallida.Molecular plant pathology · 2021Article
- Review
- Phytoparasitic Nematode Control of Plant Hormone Pathways.Plant physiology · 2019Review
- Two venom allergen-like proteins, HaVAP1 and HaVAP2, are involved in the parasitism of Heterodera avenae.Molecular plant pathology · 2019Article
- Plant Proteins and Processes Targeted by Parasitic Nematode Effectors.Frontiers in plant science · 2019Review
- COP9 Signalosome CSN4 and CSN5 Subunits Are Involved in Jasmonate-Dependent Defense Against Root-Knot Nematode in Tomato.Frontiers in plant science · 2019Article
- Signal Transduction in Plant⁻Nematode Interactions.International journal of molecular sciences · 2018Review
- Molecular mimicry modulates plant host responses to pathogens.Annals of botany · 2018Review
- Spatiotemporal deep imaging of syncytium induced by the soybean cyst nematode Heterodera glycines.Protoplasma · 2017Article
- CLE peptide-encoding gene families in Medicago truncatula and Lotus japonicus, compared with those of soybean, common bean and Arabidopsis.Scientific reports · 2017Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Like other biotrophic plant pathogens, plant-parasitic nematodes secrete effector proteins into host cells to facilitate infection. Effector proteins that mimic plant CLAVATA3/ENDOSPERM SURROUNDING REGION-related (CLE) proteins have been identified in several cyst nematodes, including the potato cyst nematode (PCN); however, the mechanistic details of this cross-kingdom mimicry are poorly understood. Plant CLEs are posttranslationally modified and proteolytically processed to function as bioactive ligands critical to various aspects of plant development. Using ectopic expression coupled with nanoliquid chromatography-tandem mass spectrometry analysis, we show that the in planta mature form of proGrCLE1, a multidomain CLE effector secreted by PCN during infection, is a 12-amino acid arabinosylated glycopeptide (named GrCLE1-1Hyp4,7g) with striking structural similarity to mature plant CLE peptides. This glycopeptide is more resistant to hydrolytic degradation and binds with higher affinity to a CLAVATA2-like receptor (StCLV2) from potato (Solanum tuberosum) than its nonglycosylated forms. We further show that StCLV2 is highly up-regulated at nematode infection sites and that transgenic potatoes with reduced StCLV2 expression are less susceptible to PCN infection, indicating that interference of the CLV2-mediated signaling pathway confers nematode resistance in crop plants. These results strongly suggest that phytonematodes have evolved to utilize host cellular posttranslational modification and processing machinery for the activation of CLE effectors following secretion into plant cells and highlight the significance of arabinosylation in regulating nematode CLE effector activity. Our finding also provides evidence that multidomain CLEs are modified and processed similarly to single-domain CLEs, adding new insight into CLE maturation in plants.
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