Evidence map›Paper›PMID 25416474›Full record

ArticlePlant physiology2015

The Arabidopsis Vacuolar Sorting Receptor1 is required for osmotic stress-induced abscisic acid biosynthesis.

Zhen-Yu Wang, Chris Gehring, Jianhua Zhu, Feng-Min Li, Jian-Kang Zhu, Liming Xiong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 60 citations in OpenAlex.

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  8. Hydrogen sulfide (HPlant cell reports · 2021
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  11. Salt Stress Signals on Demand: Cellular Events in the Right Context.International journal of molecular sciences · 2020
    Review
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  17. Natural variation identifies genes affecting drought-induced abscisic acid accumulation inProceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  18. Review
  19. Frontiers in plant science · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Zhen-Yu WangBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia (Z.-Y.W., C.G., L.X.);State Key Laboratory of Grassland Agroecosystem, Institute of Arid Agroecology, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China (Z.-Y.W., F.-M.L.);Department of Plant Science and Landscape Architecture, University of Maryland, College Park, Maryland 20742 (J.Z.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 (J.-K.Z.); andShanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Chris GehringBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia (Z.-Y.W., C.G., L.X.);State Key Laboratory of Grassland Agroecosystem, Institute of Arid Agroecology, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China (Z.-Y.W., F.-M.L.);Department of Plant Science and Landscape Architecture, University of Maryland, College Park, Maryland 20742 (J.Z.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 (J.-K.Z.); andShanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Jianhua ZhuBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia (Z.-Y.W., C.G., L.X.);State Key Laboratory of Grassland Agroecosystem, Institute of Arid Agroecology, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China (Z.-Y.W., F.-M.L.);Department of Plant Science and Landscape Architecture, University of Maryland, College Park, Maryland 20742 (J.Z.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 (J.-K.Z.); andShanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Feng-Min LiBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia (Z.-Y.W., C.G., L.X.);State Key Laboratory of Grassland Agroecosystem, Institute of Arid Agroecology, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China (Z.-Y.W., F.-M.L.);Department of Plant Science and Landscape Architecture, University of Maryland, College Park, Maryland 20742 (J.Z.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 (J.-K.Z.); andShanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Jian-Kang ZhuBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia (Z.-Y.W., C.G., L.X.);State Key Laboratory of Grassland Agroecosystem, Institute of Arid Agroecology, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China (Z.-Y.W., F.-M.L.);Department of Plant Science and Landscape Architecture, University of Maryland, College Park, Maryland 20742 (J.Z.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 (J.-K.Z.); andShanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Liming XiongBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia (Z.-Y.W., C.G., L.X.);State Key Laboratory of Grassland Agroecosystem, Institute of Arid Agroecology, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China (Z.-Y.W., F.-M.L.);Department of Plant Science and Landscape Architecture, University of Maryland, College Park, Maryland 20742 (J.Z.);Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 (J.-K.Z.); andShanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.) liming.xiong@kaust.edu.sa.
King Abdullah University of Science and Technology · SALanzhou University · CNChinese Academy of Sciences · CNShanghai Institutes for Biological Sciences · CN

Funding

CALCIUM SIGNALING--INTRACELL ION HOMEOSTASIS REGULATIONR01GM059138 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ZHU, JIAN-KANG · 1999 to 2015
$4.4M
NIGMS NIH HHS R01 GM059138NIGMS NIH HHS R01GM059138
6 · The paper itself

Abstract

Osmotic stress activates the biosynthesis of the phytohormone abscisic acid (ABA) through a pathway that is rate limited by the carotenoid cleavage enzyme 9-cis-epoxycarotenoid dioxygenase (NCED). To understand the signal transduction mechanism underlying the activation of ABA biosynthesis, we performed a forward genetic screen to isolate mutants defective in osmotic stress regulation of the NCED3 gene. Here, we identified the Arabidopsis (Arabidopsis thaliana) Vacuolar Sorting Receptor1 (VSR1) as a unique regulator of ABA biosynthesis. The vsr1 mutant not only shows increased sensitivity to osmotic stress, but also is defective in the feedback regulation of ABA biosynthesis by ABA. Further analysis revealed that vacuolar trafficking mediated by VSR1 is required for osmotic stress-responsive ABA biosynthesis and osmotic stress tolerance. Moreover, under osmotic stress conditions, the membrane potential, calcium flux, and vacuolar pH changes in the vsr1 mutant differ from those in the wild type. Given that manipulation of the intracellular pH is sufficient to modulate the expression of ABA biosynthesis genes, including NCED3, and ABA accumulation, we propose that intracellular pH changes caused by osmotic stress may play a signaling role in regulating ABA biosynthesis and that this regulation is dependent on functional VSR1.

Indexed as

Abscisic AcidArabidopsisArabidopsis ProteinsDioxygenasesGene Expression ProfilingOsmotic PressurePlant ProteinsSignal Transduction9-cis-epoxy-carotenoid dioxygenaseAbscisic AcidArabidopsis ProteinsDioxygenasesELP protein, ArabidopsisPlant Proteins

Identifiers

PMID25416474
PMCPMC4281004
OpenAlexW2085077918

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.