Evidence map›Paper›PMID 25416456›Full record

ArticlePsychometrika2016

Fitting Nonlinear Ordinary Differential Equation Models with Random Effects and Unknown Initial Conditions Using the Stochastic Approximation Expectation-Maximization (SAEM) Algorithm.

Sy-Miin Chow, Zhaohua Lu, Andrew Sherwood, Hongtu Zhu

Abstract read
In one paragraph

Article in Psychometrika, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Unsupervised Model Construction in Continuous-Time.Structural equation modeling : a multidisciplinary journal · 2025
    Article
  3. What ergodicity means for you.Developmental cognitive neuroscience · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sy-Miin ChowThe Pennsylvania State University, 413 Biobehavioral Health Building, University Park, PA, 16802 , USA. symiin@psu.edu.
Zhaohua LuUniversity of North Carolina at Chapel Hill, Chapel Hill, USA.
Andrew SherwoodDuke University, Durham, USA.
Hongtu ZhuUniversity of North Carolina at Chapel Hill, Chapel Hill, USA.

Funding

UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
Washington University ConsoritumU54EB005149 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON · 2004 to 2013
$39.3M
Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVIDIAN, MARIE, KOSOROK, MICHAEL R · 2010 to 2019
$21.3M
Statistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9M
Modeling the Dynamics of Early Communication and DevelopmentR01GM105004 · NIGMS · UNIVERSITY OF MIAMI CORAL GABLES · PI CHOW, SY-MIIN, COHN, JEFFREY F · 2013 to 2016
$2.1M
Longitudinal Analysis of Biomedical Imaging DataR21AG033387 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHU, HONGTU · 2009 to 2010
$334k
NCI NIH HHS P01 CA142538NCI NIH HHS P01CA142538-01NCRR NIH HHS RR025747-01NCRR NIH HHS UL1 RR025747NIA NIH HHS AG033387NIA NIH HHS R21 AG033387NIBIB NIH HHS EB005149-01NIBIB NIH HHS U54 EB005149NIGMS NIH HHS R01 GM105004NIGMS NIH HHS R01GM105004NIMH NIH HHS MH086633NIMH NIH HHS R01 MH086633
6 · The paper itself

Abstract

The past decade has evidenced the increased prevalence of irregularly spaced longitudinal data in social sciences. Clearly lacking, however, are modeling tools that allow researchers to fit dynamic models to irregularly spaced data, particularly data that show nonlinearity and heterogeneity in dynamical structures. We consider the issue of fitting multivariate nonlinear differential equation models with random effects and unknown initial conditions to irregularly spaced data. A stochastic approximation expectation-maximization algorithm is proposed and its performance is evaluated using a benchmark nonlinear dynamical systems model, namely, the Van der Pol oscillator equations. The empirical utility of the proposed technique is illustrated using a set of 24-h ambulatory cardiovascular data from 168 men and women. Pertinent methodological challenges and unresolved issues are discussed.

Indexed as

AlgorithmsNonlinear DynamicsStochastic ProcessesHumansModels, TheoreticalPsychometricsdifferential equationdynamiclongitudinalnonlinearstochastic EM

Identifiers

PMID25416456
PMCPMC4441616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.