ArticleBiology open2014
Length-dependent anisotropic scaling of spindle shape.
Article in Biology open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Mitotic Cdc42 waves encode PI(3,4)PScience advances · 2026Article
- Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length.Cellular and molecular life sciences : CMLS · 2021Article
- Microtubule end tethering of a processive kinesin-8 motor Kif18b is required for spindle positioning.The Journal of cell biology · 2018Article
- GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics.Journal of cell science · 2017Article
- Mitotic spindle assembly in animal cells: a fine balancing act.Nature reviews. Molecular cell biology · 2017Review
- Liquid behavior of cross-linked actin bundles.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Kinesin-5 Contributes to Spindle-length Scaling in the Evolution of Cancer toward Metastasis.Scientific reports · 2016Article
- Spindle Size Scaling Contributes to Robust Silencing of Mitotic Spindle Assembly Checkpoint.Biophysical journal · 2016Article
- Mechanisms of Mitotic Spindle Assembly.Annual review of biochemistry · 2016Review
- A versatile multivariate image analysis pipeline reveals features of Xenopus extract spindles.The Journal of cell biology · 2016Article
- Metadata management for high content screening in OMERO.Methods (San Diego, Calif.) · 2016Article
- Building the Microtubule Cytoskeleton Piece by Piece.The Journal of biological chemistry · 2015Review
- A comparative analysis of spindle morphometrics across metazoans.Current biology : CB · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Spindle length varies dramatically across species and during early development to segregate chromosomes optimally. Both intrinsic factors, such as regulatory molecules, and extrinsic factors, such as cytoplasmic volume, determine spindle length scaling. However, the properties that govern spindle shape and whether these features can be modulated remain unknown. Here, we analyzed quantitatively how the molecular players which regulate microtubule dynamics control the kinetics of spindle formation and shape. We find that, in absence of Clasp1 and Clasp2, spindle assembly is biphasic due to unopposed inward pulling forces from the kinetochore-fibers and that kinetochore-fibers also alter spindle geometry. We demonstrate that spindle shape scaling is independent of the nature of the molecules that regulate dynamic microtubule properties, but is dependent on the steady-state metaphase spindle length. The shape of the spindle scales anisotropically with increasing length. Our results suggest that intrinsic mechanisms control the shape of the spindle to ensure the efficient capture and alignment of chromosomes independently of spindle length.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.