ArticleMedical oncology (Northwood, London, England)2014
Association of FoxP3 rs3761548 polymorphism with susceptibility to colorectal cancer in the Chinese population.
Article in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The association ofBioscience reports · 2019Pooled it
- Functional Foxp3 polymorphisms and the susceptibility to cancer: An update meta-analysis.Medicine · 2018Pooled it
- Nucleotide variation in Foxp3 gene and prognosis of bladder cancer: a case-control study.Frontiers in oncology · 2025Article
- Genetic and Epigenetic Association ofInternational journal of molecular sciences · 2024Article
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- Article
- The role of FOXP3 rs3761548 and rs2294021 polymorphisms in pediatrics acute lymphoblastic leukemia: association with risk and response to therapy.Molecular biology reports · 2021Article
- The role of long non-coding RNA GAS5 in cancers.Cancer management and research · 2019Article
- Association of Foxp3 promoter polymorphisms with susceptibility to endometrial cancer in the Chinese Han women.Medicine · 2018Observational
- Transcription factor FOXP3 gene variants affect epithelial ovarian carcinoma in the Han Chinese population.International journal of clinical and experimental pathology · 2018Article
- Association of twoCancer management and research · 2018Article
- Association between FOXP3 gene polymorphisms and risk of differentiated thyroid cancer in Chinese Han population.Journal of clinical laboratory analysis · 2017Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to determine the association of the Forkhead box P3 (FoxP3) rs3761548 polymorphism with the risk of colorectal cancer (CRC). Polymorphism genotyping was detected with polymerase chain reaction-polyacrylamide gel electrophoresis (PCR-PAGE), and data revealed that the AA, AC, and the combined A variant genotype (AA+AC) conferred a significantly greater risk of CRC [OR (95% CI) = 2.806 (1.726-4.563), 1.54 (1.121-2.11), and 1.797 (1.344-2.404), respectively]. Moreover, the A allele of rs3761548 was observed to be associated with higher susceptibility of CRC [OR (95% CI) = 1.792 (1.424-2.254)]. Unfortunately, no significant association was observed between the two subgroups after stratification by clinical characteristics including age; gender; tumor size, growth pattern, or differentiation; lymph node metastasis; and TNM pathological stage. Thus, we concluded that the FoxP3 gene polymorphism contributes to CRC susceptibility in a Chinese population.
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Registered trials
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