SynthesisEuropean journal of preventive cardiology2016
Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration.
Synthesis in European journal of preventive cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Intima media thickness of carotid arteries in familial Mediterranean fever: a systematic review and meta-analysis.Clinical rheumatology · 2022Pooled it
- Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100 667 Patients.Circulation · 2020Pooled it
- The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials.Inflammopharmacology · 2018Pooled it
- Pro-Inflammatory Markers in Relation to Cardiovascular Disease in HIV Infection. A Systematic Review.PloS one · 2016Pooled it
- Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study.Scientific reports · 2023Trial
- Trial
- Biomarkers and Endothelial Damage in Obesity: An Insight into the Pharmacological Modulation.International journal of molecular sciences · 2026Review
- Circulating Markers of Inflammation and Endothelial Dysfunction Associated With Increased Progression of Internal Carotid Intima-Media Thickness in the Population-Based Framingham Heart Study.Journal of the American Heart Association · 2025Article
- Predictive value of the perivascular fat attenuation index and delta-CT-FFR for the formation of atherosclerotic plaques proximal to left anterior descending myocardial bridges.Quantitative imaging in medicine and surgery · 2025Article
- Protective Effect of Factor XIII Intron-K G Allele on Subclinical Vascular Disease.International journal of molecular sciences · 2025Article
- Association between systemic inflammation response index trajectories and carotid atherosclerosis progression.Frontiers in endocrinology · 2025Article
- Circulating Autoantibodies in Adults with Hashimoto's Thyroiditis: New Insights from a Single-Center, Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2024Article
- Seven psychiatric traits and the risk of increased carotid intima-media thickness: a Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure.Journal of atherosclerosis and thrombosis · 2023Article
- Cardiovascular Disease Risk in Children and Adolescents with Attention Deficit/Hyperactivity Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- The preliminary evidence on the association of the gut microbiota with stroke risk stratification in South Chinese population.Frontiers in cellular and infection microbiology · 2023Article
- The gut connection: Intestinal permeability as a pathway from breast cancer survivors' relationship satisfaction to inflammation across treatment.Brain, behavior, and immunity · 2022Article
- Predicting value of fibrinogen in identifying cerebrovascular ischemic events in patients with dizziness/vertigo.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies.Frontiers in psychiatry · 2022Article
- Ultrasound Methods in the Evaluation of Atherosclerosis: From Pathophysiology to Clinic.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
55 authors.
Funding
Abstract
backgroundLarge-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population.
methodsInformation on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT collaboration involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses.
resultsMean baseline CCA-IMT amounted to 0.74 mm (SD = 0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011 mm/year (SD = 0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082 mm for high-sensitivity C-reactive protein (p < 0.001); 0.0072 mm for fibrinogen (p < 0.001); and 0.0025 mm for leucocyte count (p = 0.033). 'Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p < 0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest 'inflammatory load' had a greater CCA-IMT progression (p = 0.015).
conclusionInflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its assessment within a limited time period. Our findings for 'inflammatory load' suggest important combined effects of the three inflammatory markers on early atherosclerosis.
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