ArticleJournal of the American Heart Association2014
Electrocardiographic deep terminal negativity of the P wave in V(1) and risk of sudden cardiac death: the Atherosclerosis Risk in Communities (ARIC) study.
Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Effect of intensive blood pressure lowering on left atrial remodeling in the SPRINT.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Trial
- Effect of Intensive Blood Pressure Lowering on Incident Atrial Fibrillation and P-Wave Indices in the ACCORD Blood Pressure Trial.American journal of hypertension · 2016Trial
- A hybrid algorithm-based ECG risk prediction model for cardiovascular disease.European heart journal. Digital health · 2025Article
- Association of abnormal P-wave parameters with all-cause mortality in diffuse large B-cell lymphoma.Scientific reports · 2024Article
- Association between P-wave terminal force in lead VJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Comparing the performance of machine learning and conventional models for predicting atherosclerotic cardiovascular disease in a general Chinese population.BMC medical informatics and decision making · 2023Article
- Association of electrocardiographic spatial heterogeneity of repolarization and spatial heterogeneity of atrial depolarization with left ventricular fibrosis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Prognostic value of P-wave morphology in general population.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Prognostic Value of PtfV1 in Long-Term Outcomes of Patients with Unstable Angina.International journal of general medicine · 2023Article
- Relationship Between High Blood Pressure, Atrial Cardiopathy, and Mortality in the General Population.American journal of hypertension · 2023Article
- Deep terminal negativity of the P-wave in V1 and stroke risk: The National Health and Nutrition Examination survey III.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022Article
- P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research-A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology.Circulation. Arrhythmia and electrophysiology · 2022Review
- Predictive value of electrocardiographic markers in children with dilated cardiomyopathy.Frontiers in pediatrics · 2022Review
- Article
- Relationship between resting 12-lead electrocardiogram and all-cause death in patients without structural heart disease: Shinken Database analysis.BMC cardiovascular disorders · 2021Article
- Atrial Conduction Disorders.Current cardiology reviews · 2021Review
- Assessing Atrial Fibrillation Substrates by P Wave Analysis: A Comprehensive Review.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Review
- The relationship between electrocardiographic data and mortality in children diagnosed with dilated cardiomyopathy.European journal of pediatrics · 2020Article
- Elevated red cell distribution width is associated with negative P wave amplitude in lead V1: national health and nutrition examination survey (NHANES III).American journal of cardiovascular disease · 2020Article
- P-wave vector magnitude predicts recurrence of atrial fibrillation after catheter ablation in patients with persistent atrial fibrillation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundIdentifying individuals at risk for sudden cardiac death (SCD) is of critical importance. Electrocardiographic (ECG) deep terminal negativity of P wave in V1 (DTNPV1), a marker of left atrial abnormality, has been associated with increased risk of all-cause and cardiovascular mortality. We hypothesized that DTNPV1 is associated with increased risk of sudden cardiac death (SCD). METHODS AND
resultsThis analysis included 15 375 participants (54.1±5.8 years, 45% men, 73% whites) from the Atherosclerosis Risk in Communities (ARIC) study. DTNPV1 was defined from the resting 12-lead ECG as presence of biphasic P wave (positive/negative) in V1 with the amplitude of the terminal negative phase >100 μV, or one small box on ECG scale. After a median of 14 years of follow-up, 311 cases of SCD occurred. In unadjusted Cox regression, DTNPV1 was associated with an 8-fold increased risk of SCD (HR 8.21; [95%CI 5.27 to 12.79]). Stratified by race and study center, and adjusted for age, sex, coronary heart disease (CHD), and ECG risk factors, as well as atrial fibrillation (AF), stroke, CHD, and heart failure (HF) as time-updated variables, the risk of SCD associated with DTNPV1 remained significant (2.49, [1.51-4.10]). DTNPV1 improved reclassification: additional 3.4% of individuals were appropriately reclassified into a higher SCD risk group, as compared with traditional CHD risk factors alone. In fully adjusted models DTNPV1 was associated with increased risk of non-fatal events: AF (5.02[3.23-7.80]), CHD (2.24[1.43-3.53]), HF (1.90[1.19-3.04]), and trended towards increased risk of stroke (1.88[0.99-3.57]).
conclusionDTNPV1 is predictive of SCD suggesting its potential utility in risk stratification in the general population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.