ArticlePharmaceutical research2015
Human nail plate modifications induced by onychomycosis: implications for topical therapy.
Article in Pharmaceutical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Nail tattooing: a novel and minimally invasive technique for enhancing drug penetration through the nail.Drug delivery and translational research · 2026Article
- Nail Lacquer ContainingAntibiotics (Basel, Switzerland) · 2024Article
- Is Raman Spectroscopy of Fingernails a Promising Tool for Diagnosing Systemic and Dermatological Diseases in Adult and Pediatric Populations?Medicina (Kaunas, Lithuania) · 2024Review
- Design, Development, and Evaluation of Constant Voltage Iontophoresis for the Transungual Delivery of Efinaconazole.Pharmaceutics · 2023Article
- Chitosan Nanoparticles Loaded Poloxamer 407 Gel for Transungual Delivery of Terbinafine HCl.Pharmaceutics · 2022Article
- Iontophoresis to Overcome the Challenge of Nail Permeation: Considerations and Optimizations for Successful Ungual Drug Delivery.The AAPS journal · 2021Review
- Predictive Model of Nail Consistency Using Scanning Electron Microscopy with Energy-Dispersive X-Ray.Biology · 2021Article
- Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails.Molecules (Basel, Switzerland) · 2021Article
- Formulation of Tioconazole andMolecules (Basel, Switzerland) · 2020Article
- Once Weekly Application of Urea 40% and Bifonazole 1% Leads to Earlier Nail Removal in Onychomycosis.Skin appendage disorders · 2020Article
- Potential of Naftifine Application for Transungual Delivery.Molecules (Basel, Switzerland) · 2020Article
- Potential of Chemical and Physical Enhancers for Transungual Delivery of Amorolfine Hydrochloride.Materials (Basel, Switzerland) · 2019Article
- An investigation of how fungal infection influences drug penetration through onychomycosis patient's nail plates.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2016Article
- Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success.Journal of fungi (Basel, Switzerland) · 2015Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThrough the characterisation of the human onchomycotic nail plate this study aimed to inform the design of new topical ungual formulations.
methodsThe mechanical properties of the human nail were characterised using a Lloyd tensile strength tester. The nail's density was determined via pycnometry and the nail's ultrastructure by electron microscopy. Raman spectroscopy analysed the keratin disulphide bonds within the nail and its permeability properties were assessed by quantifying water and rhodamine uptake.
resultsChronic in vivo nail plate infection increased human nailplate thickness (healthy 0.49 ± 0.15 mm; diseased 1.20 ± 0.67 mm), but reduced its tensile strength (healthy 63.7 ± 13.4 MPa; diseased 41.7 ± 5.0 MPa) and density (healthy 1.34 ± 0.01 g/cm(3); diseased 1.29 ± 0.00 g/cm(3)). Onchomycosis caused cell-cell separation, without disrupting the nail disulfide bonds or desmosomes. The diseased and healthy nails showed equivalent water uptake profiles, but the rhodamine penetration was 4-fold higher in the diseased nails using a PBS vehicle and 3 -fold higher in an ethanol/PBS vehicle.
conclusionsOnchomycotic nails presented a thicker but more porous barrier, and its eroded intracellular matrix rendered the tissue more permeable to topically applied chemicals when an aqueous vehicle was used.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.