ArticleThe Plant cell2014
BRASSINOSTEROID INSENSITIVE2 interacts with ABSCISIC ACID INSENSITIVE5 to mediate the antagonism of brassinosteroids to abscisic acid during seed germination in Arabidopsis.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 2 of them syntheses that pooled it.
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Who cites it
144 citing papers in PubMed, 2 syntheses or guidelines pooled it, 298 citations in OpenAlex.
- Transcriptome meta-analysis-based identification of hub transcription factors and RNA-binding proteins potentially orchestrating gene regulatory cascades and crosstalk in response to abiotic stresses in Arabidopsis thaliana.Journal of applied genetics · 2024Pooled it
- Dry side of the core: a meta-analysis addressing the original nature of the ABA signalosome at the onset of seed imbibition.Frontiers in plant science · 2023Pooled it
- SDR3.1 negatively regulates seed dormancy in Poaceae crops.The Plant journal : for cell and molecular biology · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Molecular mechanism of abscisic acid regulating bud-break through the NnTIFY10A/B-NnABI5 module in lotus.Horticulture research · 2026Article
- Abscisic acid interplay with phytohormones, plant growth regulators and signaling molecules in orchestrating an elaborate crosstalk for stress resilience in plants.Biologia futura · 2026Review
- Omics-based characterization of physiological and transcriptomic resilience during cold de-acclimation and re-acclimation in GSK-like kinase mutants.BMC plant biology · 2026Article
- Cracking the Hard Seed: Molecular Mechanisms and Multi-Omics Insights into Seed Dormancy and Germination in the GenusInternational journal of molecular sciences · 2026Review
- An underutilized genetic component in the regulation of soybean seed weight.Nature communications · 2026Article
- Deciphering germination rate differences in quinoa genotypes via integrated phenotypic, structural, and transcriptomic approaches.BMC plant biology · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- Multifaceted Roles of SPL9 in Plant Growth, Development, and Stress Responses: A Review.Plants (Basel, Switzerland) · 2026Review
- OsDi19-1 Acts Downstream of OsABI5 to Negatively Regulate ABA-Inhibited Seed Germination and Seedling Growth in Rice.Rice (New York, N.Y.) · 2026Article
- Mediator subunit MED25 represses ABI5-dependent activation of erucic acid biosynthetic geneFrontiers in plant science · 2026Article
- Advances in deciphering the mechanisms of salt tolerance in Maize.Plant signaling & behavior · 2025Review
- Mapping the Phosphorylation Regulatory Network of Single-Celled Fibre Elongation Mediated by GhBIN2 in Cotton.Plant biotechnology journal · 2025Article
- Physiological and Molecular Responses of Seed Germination to Irrigating-Sowing in Drought-Stressed Foxtail Millet (Plants (Basel, Switzerland) · 2025Article
- From Hormones to Harvests: A Pathway to Strengthening Plant Resilience for Achieving Sustainable Development Goals.Plants (Basel, Switzerland) · 2025Review
- A mini-review on the role of leucine-rich repeat receptor-like kinases (LRR-RLKs) in plant responses to drought stress.Molecular biology reports · 2025Review
- Identification of F-box proteins in ABA- and GA-regulated seed germination: interaction of GASA1 signalling peptide and ABA-induced ubiquitination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
84 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seed germination and postgerminative growth are regulated by a delicate hormonal balance. Abscisic acid (ABA) represses Arabidopsis thaliana seed germination and postgerminative growth, while brassinosteroids (BRs) antagonize ABA-mediated inhibition and promote these processes. However, the molecular mechanism underlying BR-repressed ABA signaling remains largely unknown. Here, we show that the Glycogen Synthase Kinase 3-like kinase BRASSINOSTEROID INSENSITIVE2 (BIN2), a critical repressor of BR signaling, positively regulates ABA responses during seed germination and postgerminative growth. Mechanistic investigation revealed that BIN2 physically interacts with ABSCISIC ACID INSENSITIVE5 (ABI5), a bZIP transcription factor. Further genetic analysis demonstrated that the ABA-hypersensitive phenotype of BIN2-overexpressing plants requires ABI5. BIN2 was found to phosphorylate and stabilize ABI5 in the presence of ABA, while application of epibrassinolide (the active form of BRs) inhibited the regulation of ABI5 by BIN2. Consistently, the ABA-induced accumulation of ABI5 was affected in BIN2-related mutants. Moreover, mutations of the BIN2 phosphorylation sites on ABI5 made the mutant protein respond to ABA improperly. Additionally, the expression of several ABI5 regulons was positively modulated by BIN2. These results provide evidence that BIN2 phosphorylates and stabilizes ABI5 to mediate ABA response during seed germination, while BRs repress the BIN2-ABI5 cascade to antagonize ABA-mediated inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.