ArticleMolecular biology and evolution2015
Feather development genes and associated regulatory innovation predate the origin of Dinosauria.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
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- Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural research.Nature communications · 2021Article
- Folding Keratin Gene Clusters during Skin Regional Specification.Developmental cell · 2020Article
- Prospects for sociogenomics in avian cooperative breeding and parental care.Current zoology · 2020Article
- Noncoding regions underpin avian bill shape diversification at macroevolutionary scales.Genome research · 2020Article
- Characterization of Embryonic Skin Transcriptome inG3 (Bethesda, Md.) · 2020Article
- Sub-lethal effects of permethrin exposure on a passerine: implications for managing ectoparasites in wild bird nests.Conservation physiology · 2020Article
- Integrating natural history collections and comparative genomics to study the genetic architecture of convergent evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Comprehensive molecular and cellular studies suggest avian scutate scales are secondarily derived from feathers, and more distant from reptilian scales.Scientific reports · 2018Article
- Genetic and Molecular Basis of Feather Diversity in Birds.Genome biology and evolution · 2018Review
- Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion.Molecular biology and evolution · 2018Article
- Conserved Nonexonic Elements: A Novel Class of Marker for Phylogenomics.Systematic biology · 2017Article
- Using scale and feather traits for module construction provides a functional approach to chicken epidermal development.Functional & integrative genomics · 2017Article
- Exceptional preservation and the fossil record of tetrapod integument.Proceedings. Biological sciences · 2017Article
- Systematic analysis of transcription start sites in avian development.PLoS biology · 2017Article
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
The evolution of avian feathers has recently been illuminated by fossils and the identification of genes involved in feather patterning and morphogenesis. However, molecular studies have focused mainly on protein-coding genes. Using comparative genomics and more than 600,000 conserved regulatory elements, we show that patterns of genome evolution in the vicinity of feather genes are consistent with a major role for regulatory innovation in the evolution of feathers. Rates of innovation at feather regulatory elements exhibit an extended period of innovation with peaks in the ancestors of amniotes and archosaurs. We estimate that 86% of such regulatory elements and 100% of the nonkeratin feather gene set were present prior to the origin of Dinosauria. On the branch leading to modern birds, we detect a strong signal of regulatory innovation near insulin-like growth factor binding protein (IGFBP) 2 and IGFBP5, which have roles in body size reduction, and may represent a genomic signature for the miniaturization of dinosaurian body size preceding the origin of flight.
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