ArticleMedicine2014
Young patients (≤ 35 years old) with colorectal cancer have worse outcomes due to more advanced disease: a 30-year retrospective review.
Article in Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk of lymph-node metastasis in early onset T1 colorectal cancer: a systematic review and meta-analysis.Journal of gastroenterology · 2026Pooled it
- Survival rate of colorectal cancer in China: A systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Survival in Young-Onset Metastatic Colorectal Cancer: Findings From Cancer and Leukemia Group B (Alliance)/SWOG 80405.Journal of the National Cancer Institute · 2022Trial
- Development of a Novel Psychosocial Intervention to Improve Symptom Management for Adolescents and Young Adults with Advanced or Recurrent Cancer.Journal of adolescent and young adult oncology · 2026Article
- Characteristics and outcomes of patients undergoing colonoscopy in Gaza Strip hospitals: a retrospective study.BMC gastroenterology · 2026Article
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- Trends, global comparisons, and projections of early onset colorectal cancer burden in China based on GBD study 2021.Scientific reports · 2025Article
- A multivariate model of IVIM-DWI in the preoperative diagnosis of tumor budding grade in rectal cancer.Frontiers in oncology · 2025Article
- Postoperative adjuvant chemotherapy in patients with stage II early onset colorectal cancer: exploration and discovery using real-world data and the SEER database.Frontiers in oncology · 2025Article
- Article
- Prognostic analysis of systemic antitumor therapy in young patients with advanced liver cancer: A cohort study.Oncology letters · 2024Article
- A Survey Detailing Early Onset Colorectal Cancer Patient and Caregiver Experiences in Canada.Current oncology (Toronto, Ont.) · 2024Article
- Age-related trends in the incidence of metastatic colorectal cancer from 2010 to 2019 in the USA.Future oncology (London, England) · 2024Observational
- Stereotactic body radiation therapy for lung metastases from colorectal cancer: outcomes and prognostic factors in a series of 109 patients.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024Article
- Focusing on colorectal cancer in young adults (Review).Molecular and clinical oncology · 2024Review
- Early-Onset Colon Cancer: A Narrative Review of Its Pathogenesis, Clinical Presentation, Treatment, and Prognosis.Cureus · 2023Review
- Association of Age With Treatment-Related Adverse Events and Survival in Patients With Metastatic Colorectal Cancer.JAMA network open · 2023Article
- A Retrospective Multicenter Study of the Clinicopathological Characteristics and Prognosis of Young Adult Patients with Colorectal Cancer: Effects of Chemotherapy on Prognosis.Journal of clinical medicine · 2023Article
- Reranking cancer mortality using years of life lost.JNCI cancer spectrum · 2023Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An appropriate cutoff of age and the impact of age on colorectal cancer outcomes remain unclear and need to be explored, particularly in China.In total, 2460 colorectal cancer patients were studied retrospectively. All patients were divided into 6 groups according to their ages at the time of diagnosis: ≤ 30, 31 to 35, 36 to 40, 41 to 45, 46 to 50, and ≥ 50 years. A suitable cutoff age for defining young adult colorectal cancer was explored according to the distribution of survival in each group. Clinical characteristics and prognosis between the young adult group and the older group were then compared.According to the survival curves for each group, 35 years old was considered a suitable cutoff age for defining young adult colorectal cancer. There were 140 (5.7%) and 2320 (94.3%) cases in the young adult and older groups, respectively. The proportion of stage III-IV tumors was significantly higher in the young adult group (69.3%) than in the older group (46.4%) (P = 0.000). The univariate analysis showed that the 5-year overall survival (OS) rate and the 10-year OS rate in the young adult group were 48.9% and 38.6%, respectively, whereas in the older group, they were 63.6% and 56.9%, respectively. The young adult group had a worse prognosis (P = 0.000). The multivariate analysis showed that age was not an independent prognostic factor (relative risk 0.787, P = 0.062). After adjusting for tumor stage, the hazard proportion of death in the young adult group increased by 27.6%, but this difference was not significant (P = 0.053). Stratified analyses showed that the young adults with stage IV tumors had a worse survival rate (P = 0.046).Patients ≤ 35 years who were diagnosed with colorectal cancer had a worse prognosis because of a higher proportion of advanced stage tumors. When stage-to-stage analysis was performed, it was found that young adult colorectal cancer patients had a worse outcome only if they had stage IV tumors.
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