ReviewCurrent opinion in nephrology and hypertension2015
Vascular effects of dietary salt.
Review in Current opinion in nephrology and hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Dietary Intake and Arterial Stiffness in Children and Adolescents: A Systematic Review.Nutrients · 2023Pooled it
- Current Data on Dietary Sodium, Arterial Structure and Function in Humans: A Systematic Review.Nutrients · 2019Pooled it
- Sequential nephron blockade with combined diuretics improves diastolic function in patients with resistant hypertension.ESC heart failure · 2020Trial
- Cerebral vasomotor reactivity during hypo- and hypercapnia across the adult lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Controlled Feeding of an 8-d, High-Dairy Cheese Diet Prevents Sodium-Induced Endothelial Dysfunction in the Cutaneous Microcirculation of Healthy, Older Adults through Reductions in Superoxide.The Journal of nutrition · 2020Trial
- Apocynin and Tempol ameliorate dietary sodium-induced declines in cutaneous microvascular function in salt-resistant humans.American journal of physiology. Heart and circulatory physiology · 2019Trial
- Hemodynamic and Autonomic Response to Different Salt Intakes in Normotensive Individuals.Journal of the American Heart Association · 2016Trial
- Study Protocol for the Daasanach Human Biology Project: A Longitudinal Study of the Impact of Drinking Water Salinity and Heat Stress on Water Insecurity, Hydration, Energetics, Hypertension, and Kidney Function in Northern Kenya.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Drinking Water NaCl Is Associated With Hypertension and Albuminuria: A Panel Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Nonatherosclerotic Cardiovascular Disease in Chronic Kidney Disease.Cardiology clinics · 2025Review
- Single-cell RNA sequencing reveals that a high salt diet increases IL6R-JAK1-STAT3 gene signaling pathway activity in intestinal B cells and Tfh cells of salt-sensitive hypertension animal model.Scientific reports · 2025Article
- Focusing on perihematomal hypoperfusion following intracerebral hemorrhage: from oxidative stress to prospective therapeutic approaches.Frontiers in physiology · 2025Article
- Augmentation of Nitric Oxide Deficient Hypertension by High Salt Diet Is Associated With Reduced TNF-α Receptor Type 1 Expression in the Kidneys.American journal of hypertension · 2024Article
- Sodium Intake and Cause-Specific Mortality Among Predominantly Low-Income Black and White US Residents.JAMA network open · 2024Article
- Erythrocyte glycocalyx sensitivity to sodium is associated with salt sensitivity of blood pressure in women but not men.Frontiers in nutrition · 2024Article
- The damaging duo: Obesity and excess dietary salt contribute to hypertension and cardiovascular disease.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
- Dietary sodium to potassium ratio is an independent predictor of cardiovascular events: a longitudinal follow-up study.BMC public health · 2023Article
- Vascular Aging: Assessment and Intervention.Clinical interventions in aging · 2023Review
- Sudden Infant Death Syndrome, Pulmonary Edema, and Sodium Toxicity: A Grounded Theory.Diseases (Basel, Switzerland) · 2022Article
- Independent and interactive associations of dietary nitrate and salt intake with blood pressure and cognitive function: a cross-sectional analysis in the InCHIANTI study.International journal of food sciences and nutrition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewHigh dietary salt intake is detrimental in hypertensive and salt-sensitive individuals; however, there are a large number of normotensive salt-resistant individuals for whom dietary salt may also be harmful as a result of the blood pressure-independent effects of salt. This review will focus on the growing evidence that salt has adverse effects on the vasculature, independent of blood pressure. RECENT
findingsData from both animal and human studies provide evidence that salt impairs endothelial function and increases arterial stiffness, independent of blood pressure. High dietary salt results in oxidative stress and increased endothelial cell stiffness, which impair endothelial function, whereas transforming growth factor beta promotes increased arterial stiffness in the presence of endothelial dysfunction. SUMMARY: Health policies and most clinical research are focused on the adverse effects of dietary salt on blood pressure; however, there is an increasing body of evidence to support a deleterious effect of dietary salt on endothelial function and arterial stiffness independent of blood pressure. Endothelial dysfunction and increased arterial stiffness are predictors of cardiovascular disease; therefore, reducing excess dietary salt should be considered important for overall vascular health in addition to blood pressure.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.