ArticleACS nano2014
Multiwalled nanotubes formed by catanionic mixtures of drug amphiphiles.
Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Small-angle scattering studies on diverse peptide-based nanotube and helical ribbon structures reveal distinct form and structure factors.Journal of applied crystallography · 2025Article
- Stability of Nanopeptides: Structure and Molecular Exchange of Self-assembled Peptide Fibers.ACS nano · 2023Article
- Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery.AAPS PharmSciTech · 2021Review
- Supramolecular peptide nano-assemblies for cancer diagnosis and therapy: from molecular design to material synthesis and function-specific applications.Journal of nanobiotechnology · 2021Review
- Directed Assembly of Multi-Walled Nanotubes and Nanoribbons of Amino Acid Amphiphiles Using a Layer-by-Layer Approach.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- The Interaction of Supramolecular Anticancer Drug Amphiphiles with Phospholipid Membranes.Nanoscale advances · 2021Article
- Characterizing aggregate growth and morphology of alanine-rich polypeptides as a function of sequence chemistry and solution temperature from scattering, spectroscopy, and microscopy.Biophysical chemistry · 2020Article
- The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy.Asian journal of pharmaceutical sciences · 2020Article
- Self-assembling prodrug nanotherapeutics for synergistic tumor targeted drug delivery.Acta biomaterialia · 2020Review
- Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications.International journal of molecular sciences · 2019Review
- Peptide Tectonics: Encoded Structural Complementarity Dictates Programmable Self-Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Review
- Nanotherapeutic systems for local treatment of brain tumors.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- Self-assembling prodrugs.Chemical Society reviews · 2017Review
- Article
- Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design.Interface focus · 2017Review
- Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology.Chemical Society reviews · 2017Review
- Instant Hydrogelation Inspired by Inflammasomes.Angewandte Chemie (International ed. in English) · 2017Article
- Molecular design and synthesis of self-assembling camptothecin drug amphiphiles.Acta pharmacologica Sinica · 2017Article
- Peptide-drug conjugates as effective prodrug strategies for targeted delivery.Advanced drug delivery reviews · 2017Review
- One-Component Supramolecular Filament Hydrogels as Theranostic Label-Free Magnetic Resonance Imaging Agents.ACS nano · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Mixing of oppositely charged amphiphilic molecules (catanionic mixing) offers an attractive strategy to produce morphologies different from those formed by individual molecules. We report here on the use of catanionic mixing of anticancer drug amphiphiles to construct multiwalled nanotubes containing a fixed and high drug loading. We found that the molecular mixing ratio, the solvent composition, the overall drug concentrations, as well as the molecular design of the studied amphiphiles are all important experimental parameters contributing to the tubular morphology. We believe these results demonstrate the remarkable potential that anticancer drugs could offer to self-assemble into discrete nanostructures and also provide important insight into the formation mechanism of nanotubes by catanionic mixtures. Our preliminary animal studies reveal that the CPT nanotubes show significantly prolonged retention time in the tumor site after intratumoral injection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.