ArticleMolecules (Basel, Switzerland)2014
Synthesis and biological evaluation of new pleuromutilin derivatives as antibacterial agents.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Design and Synthesis of Pleuromutilin Derivatives as Antibacterial Agents Using Quantitative Structure-Activity Relationship Model.International journal of molecular sciences · 2024Article
- Activity of aurisin A isolated fromSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Antimicrobial activity, chemical composition and mechanism of action of Chinese chive (Frontiers in microbiology · 2022Article
- Cprp-An Unusual, Repetitive Protein Which Impacts Pleuromutilin Biosynthesis in the BasidiomyceteFrontiers in fungal biology · 2021Article
- Biocontrol of tomato bacterial wilt by the new strain Bacillus velezensis FJAT-46737 and its lipopeptides.BMC microbiology · 2020Article
- Article
- An antimycobacterial pleuromutilin analogue effective against dormant bacilli.Bioorganic & medicinal chemistry · 2018Article
- Structure-Activity Relationships of the Main Bioactive Constituents ofDrug metabolism and disposition: the biological fate of chemicals · 2018Article
- A streptomycin resistance marker inPeerJ · 2018Article
- A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter baumannii.Journal of medicinal chemistry · 2017Article
- Synthesis and Pharmacological Evaluation of Novel Pleuromutilin Derivatives with Substituted Benzimidazole Moieties.Molecules (Basel, Switzerland) · 2016Article
- Antibacterial, cytotoxic and genotoxic activity of nitrogenated and haloid derivatives of CLipids in health and disease · 2016Article
- Polyprenols of Ginkgo biloba Enhance Antibacterial Activity of Five Classes of Antibiotics.BioMed research international · 2016Article
- In vivo efficacy and toxicity studies of a novel antibacterial agent: 14-o-[(2-amino-1,3,4-thiadiazol-5-yl)thioacetyl] mutilin.Molecules (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Several pleuromutilin derivatives possessing thiadiazole moieties were synthesized via acylation reactions under mild conditions. The in vitro antibacterial activities of the derivatives against methicillin-resistant S. aureus, methicillin-resistant S. epidermidis, S. aureus, S. epidermidis, E. coli, and B. cereus were tested by the agar dilution method and Oxford cup assay. All the screened compounds displayed potent activity. Compound 6d was the most active antibacterial agent because of its lowest MIC value and largest inhibition zone. Docking experiments were performed to understand the possible mode of the interactions between the derivatives and 50S ribosomal subunit. Moreover, the absorption, distribution, metabolism, excretion and toxicity properties of the synthesized compounds were analyzed after prediction using the Advanced Chemistry Development/Percepta Platform available online.
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