Evidence map›Paper›PMID 25415461›Full record

ArticleACS nano2014

Turning erythrocytes into functional micromotors.

Zhiguang Wu, Tianlong Li, Jinxing Li, Wei Gao, Tailin Xu, Caleb Christianson, Weiwei Gao, Michael Galarnyk, Qiang He, Liangfang Zhang and 1 more

Abstract read
In one paragraph

Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

  1. Review
  2. Review
  3. CAMP: Closed-Loop Acoustic-Magnetic Propulsion of Microrobots for Precision Cell Manipulation.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  4. Review
  5. Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth.Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
  6. Review
  7. Stimuli-responsive hybrid materials for 4DMaterials today. Bio · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhiguang WuDepartment of Nanoengineering, University of California, San Diego , La Jolla, California 92093, United States.
Tianlong Li
Jinxing Li
Wei Gao
Tailin Xu
Caleb Christianson
Weiwei Gao
Michael Galarnyk
Qiang He
Liangfang Zhang
Joseph Wang

Funding

Innate Antimicrobial Nanotherapeutics for the Treatment of H. pylori InfectionR01DK095168 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, LIANGFANG · 2012 to 2016
$1.6M
NIDDK NIH HHS R01 DK095168NIDDK NIH HHS R01DK095168
6 · The paper itself

Abstract

Attempts to apply artificial nano/micromotors for diverse biomedical applications have inspired a variety of strategies for designing motors with diverse propulsion mechanisms and functions. However, existing artificial motors are made exclusively of synthetic materials, which are subject to serious immune attack and clearance upon entering the bloodstream. Herein we report an elegant approach that turns natural red blood cells (RBCs) into functional micromotors with the aid of ultrasound propulsion and magnetic guidance. Iron oxide nanoparticles are loaded into the RBCs, where their asymmetric distribution within the cells results in a net magnetization, thus enabling magnetic alignment and guidance under acoustic propulsion. The RBC motors display efficient guided and prolonged propulsion in various biological fluids, including undiluted whole blood. The stability and functionality of the RBC motors, as well as the tolerability of regular RBCs to the ultrasound operation, are carefully examined. Since the RBC motors preserve the biological and structural features of regular RBCs, these motors possess a wide range of antigenic, transport, and mechanical properties that common synthetic motors cannot achieve and thus hold considerable promise for a number of practical biomedical uses.

Indexed as

AnimalsBiological TransportBiomimeticsCell LineErythrocytesMacrophagesMaleMiceMicrotechnologybiocompatibilitymagnetic guidancered blood cellssynthetic motorultrasoundwhole blood

Identifiers

PMID25415461
PMCPMC4386663

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.