ArticleJournal of biomedical optics2014
Multiphoton gradient index endoscopy for evaluation of diseased human prostatic tissue ex vivo.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Intraoperative Techniques Aiding Margin Assessment and Nerve Sparing During Robot-Assisted Radical Prostatectomy.Cancers · 2026Review
- Towards next-generation diagnostic pathology: AI-empowered label-free multiphoton microscopy.Light, science & applications · 2024Review
- Two-photon microendoscope for label-free imaging in stereotactic neurosurgery.Biomedical optics express · 2023Article
- Value of multiphoton microscopy in uro-oncology: a narrative review.Translational andrology and urology · 2023Review
- Two-Photon Endoscopy: State of the Art and Perspectives.Molecular imaging and biology · 2023Review
- Article
- Label-free detection of residual breast cancer after neoadjuvant chemotherapy using biomedical multiphoton microscopy.Lasers in medical science · 2019Article
- A biopsy-needle compatible varifocal multiphoton rigid probe for depth-resolved optical biopsy.Journal of biophotonics · 2019Article
- Miniature fiber-optic multiphoton microscopy system using frequency-doubled femtosecond Er-doped fiber laser.Biomedical optics express · 2016Article
- Third harmonic generation imaging for fast, label-free pathology of human brain tumors.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Multiphoton microscopy can instantly visualize cellular details in unstained tissues. Multiphoton probes with clinical potential have been developed. This study evaluates the suitability of multiphoton gradient index (GRIN) endoscopy as a diagnostic tool for prostatic tissue. A portable and compact multiphoton endoscope based on a 1-mm diameter, 8-cm length GRIN lens system probe was used. Fresh ex vivo samples were obtained from 14 radical prostatectomy patients and benign and malignant areas were imaged and correlated with subsequent H&E sections. Multiphoton GRIN endoscopy images of unfixed and unprocessed prostate tissue at a subcellular resolution are presented. We note several differences and identifying features of benign versus low-grade versus high-grade tumors and are able to identify periprostatic tissues such as adipocytes, periprostatic nerves, and blood vessels. Multiphoton GRIN endoscopy can be used to identify both benign and malignant lesions in ex vivo human prostate tissue and may be a valuable diagnostic tool for real-time visualization of suspicious areas of the prostate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.