ArticlePloS one2014
Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Ultra-High-Field MRI in the Diagnosis and Management of Gliomas: A Systematic Review.Frontiers in neurology · 2022Pooled it
- Cerebral and tumoral blood flow in adult gliomas: a systematic review of results from magnetic resonance imaging.The British journal of radiology · 2021Pooled it
- A paired dataset of T1- and T2-weighted MRI at 3 Tesla and 7 Tesla.Scientific data · 2023Article
- Advanced MR Techniques for Preoperative Glioma Characterization: Part 1.Journal of magnetic resonance imaging : JMRI · 2023Review
- Minimally invasive treatment for glioblastoma through endoscopic surgery including tumor embolization when necessary: a technical note.Frontiers in neurology · 2023Article
- 7 Tesla and Beyond: Advanced Methods and Clinical Applications in Magnetic Resonance Imaging.Investigative radiology · 2021Review
- MRI with ultrahigh field strength and high-performance gradients: challenges and opportunities for clinical neuroimaging at 7 T and beyond.European radiology experimental · 2021Review
- Optical tissue clearing and machine learning can precisely characterize extravasation and blood vessel architecture in brain tumors.Communications biology · 2021Article
- Computational modelling of perivascular-niche dynamics for the optimization of treatment schedules for glioblastoma.Nature biomedical engineering · 2021Article
- Emerging Use of Ultra-High-Field 7T MRI in the Study of Intracranial Vascularity: State of the Field and Future Directions.AJNR. American journal of neuroradiology · 2020Review
- Stimulus-evoked changes in cerebral vessel diameter: A study in healthy humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- In vivo detection of 2-hydroxyglutarate in brain tumors by optimized point-resolved spectroscopy (PRESS) at 7T.Magnetic resonance in medicine · 2017Article
- Glioma vessel abnormality quantification using time-of-flight MR angiography.Magma (New York, N.Y.) · 2016Article
- MicroCT angiography detects vascular formation and regression in skin wound healing.Microvascular research · 2016Article
- Markers of Response to Antiangiogenic Therapies in Colorectal Cancer: Where Are We Now and What Should Be Next?Clinical Medicine Insights. Oncology · 2016Review
- Advanced MR Imaging in Neuro-oncology.Clinical neuroradiology · 2015Review
- [Towards more precision in the therapy of brain tumors. Possibilities and limits of MRI].Der Nervenarzt · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze if tumor vessels can be visualized, segmented and quantified in glioblastoma patients with time of flight (ToF) angiography at 7 Tesla and multiscale vessel enhancement filtering. MATERIALS AND
methodsTwelve patients with newly diagnosed glioblastoma were examined with ToF angiography (TR = 15 ms, TE = 4.8 ms, flip angle = 15°, FOV = 160 × 210 mm(2), voxel size: 0.31 × 0.31 × 0.40 mm(3)) on a whole-body 7 T MR system. A volume of interest (VOI) was placed within the border of the contrast enhancing part on T1-weighted images of the glioblastoma and a reference VOI was placed in the non-affected contralateral white matter. Automated segmentation and quantification of vessels within the two VOIs was achieved using multiscale vessel enhancement filtering in ImageJ.
resultsTumor vessels were clearly visible in all patients. When comparing tumor and the reference VOI, total vessel surface (45.3 ± 13.9 mm(2) vs. 29.0 ± 21.0 mm(2) (p<0.035)) and number of branches (3.5 ± 1.8 vs. 1.0 ± 0.6 (p<0.001) per cubic centimeter were significantly higher, while mean vessel branch length was significantly lower (3.8 ± 1.5 mm vs 7.2 ± 2.8 mm (p<0.001)) in the tumor. DISCUSSION: ToF angiography at 7-Tesla MRI enables characterization and quantification of the internal vascular morphology of glioblastoma and may be used for the evaluation of therapy response within future studies.
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