Evidence map›Paper›PMID 25415318›Full record

ArticlePloS one2014

Enteroaggregative Escherichia coli have evolved independently as distinct complexes within the E. coli population with varying ability to cause disease.

Marie Anne Chattaway, Claire Jenkins, Dunstan Rajendram, Alejandro Cravioto, Kaisar Ali Talukder, Tim Dallman, Anthony Underwood, Steve Platt, Iruka N Okeke, John Wain

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Microbiology and epidemiology of enteroaggregativeJournal of medical microbiology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Preponderance ofFrontiers in microbiology · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Diarrheagenic Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2016
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Marie Anne ChattawayGastrointestinal Bacteria Reference Unit, Public Health England, London, United Kingdom.
Claire JenkinsGastrointestinal Bacteria Reference Unit, Public Health England, London, United Kingdom.
Dunstan RajendramGenomic Service Unit, Public Health England, London, United Kingdom.
Alejandro CraviotoInternational Vaccine Institute, Gwanak-gu, Seoul, Republic of Korea; Centre for Food and Water Borne Diseases, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Kaisar Ali TalukderInternational Vaccine Institute, Gwanak-gu, Seoul, Republic of Korea.
Tim DallmanGastrointestinal Bacteria Reference Unit, Public Health England, London, United Kingdom.
Anthony UnderwoodBioinformatics, PHE, London, United Kingdom.
Steve PlattBioinformatics, PHE, London, United Kingdom.
Iruka N OkekeHaverford College, Haverford, Pennsylvania, United States of America.
John WainNorwich Medical School, University of East Anglia, Norwich, United Kingdom.
Public Health England · GBHaverford College · USInternational Centre for Diarrhoeal Disease Research · BDInternational Vaccine Institute · KRUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enteroaggregative E. coli (EAEC) is an established diarrhoeagenic pathotype. The association with virulence gene content and ability to cause disease has been studied but little is known about the population structure of EAEC and how this pathotype evolved. Analysis by Multi Locus Sequence Typing of 564 EAEC isolates from cases and controls in Bangladesh, Nigeria and the UK spanning the past 29 years, revealed multiple successful lineages of EAEC. The population structure of EAEC indicates some clusters are statistically associated with disease or carriage, further highlighting the heterogeneous nature of this group of organisms. Different clusters have evolved independently as a result of both mutational and recombination events; the EAEC phenotype is distributed throughout the population of E. coli.

Indexed as

BangladeshEscherichia coliEscherichia coli InfectionsEscherichia coli ProteinsEvolution, MolecularHumansMultilocus Sequence TypingMutationNigeriaPhylogenyPolymerase Chain ReactionRecombination, GeneticSpecies SpecificityUnited KingdomVirulenceEscherichia coli Proteins

Identifiers

PMID25415318
PMCPMC4240581
OpenAlexW2021240617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.