Evidence map›Paper›PMID 25415230›Full record

ArticleNature communications2014

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer.

Dimple Chakravarty, Andrea Sboner, Sujit S Nair, Eugenia Giannopoulou, Ruohan Li, Sven Hennig, Juan Miguel Mosquera, Jonathan Pauwels, Kyung Park, Myriam Kossai and 16 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 363 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
363citing papers in PubMed, 2 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

363 citing papers in PubMed, 2 syntheses or guidelines pooled it, 629 citations in OpenAlex.

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  5. Differential expression of NEAT1 and miR-506-3p in triple-negative breast cancer: potential tissue-based diagnostic biomarkers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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303 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 11 institutions in 5 countries.

Dimple Chakravarty1] Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA.
Andrea Sboner1] Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA [3] Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA.
Sujit S NairDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, George Washington University, Washington DC 20037, USA.
Eugenia Giannopoulou1] Biological Sciences Department, New York City College of Technology, City University of New York, Brooklyn, New York 11201, USA [2] Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York 10021, USA.
Ruohan LiSchool of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia.
Sven HennigChemical Genomics Centre, 44227 Dortmund, Germany.
Juan Miguel Mosquera1] Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA.
Jonathan PauwelsDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA.
Kyung ParkDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA.
Myriam Kossai1] Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA.
Theresa Y MacDonaldDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA.
Jacqueline Fontugne1] Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA.
Nicholas ErhoResearch and Development, GenomeDx Biosciences, Vancouver, British Columbia, Canada V6B 1B8.
Ismael A VergaraResearch and Development, GenomeDx Biosciences, Vancouver, British Columbia, Canada V6B 1B8.
Mercedeh GhadessiResearch and Development, GenomeDx Biosciences, Vancouver, British Columbia, Canada V6B 1B8.
Elai DavicioniResearch and Development, GenomeDx Biosciences, Vancouver, British Columbia, Canada V6B 1B8.
Robert B JenkinsDepartment of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Nallasivam Palanisamy1] Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48105, USA [2] Henry Ford Health System, Medical Group Urology - Prostate Cancer Research, 1 Ford Place, Room 2D26, Detroit, Michigan 48202, USA.
Zhengming ChenDivision of Biostatistics and Epidemiology, Department of Public Health, Weill Cornell Medical College, New York, New York 10021, USA.
Shinichi NakagawaRNA Biology Laboratory, RIKEN Advanced Research Institute, Hirosawa 2-1, Wako 351-0198, Japan.
Tetsuro HiroseInstitute for Genetic Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo 060-0815, Japan.
Neil H BanderDepartment of Urology, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA.
Himisha Beltran1] Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA.
Archa H FoxSchool of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia.
Olivier Elemento1] Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA [2] Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA.
Mark A Rubin1] Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 413 East 69th Street, Room 1402, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA.
Cornell University · USGenome British Columbia · CAUniversity of Western Australia · AUChemical Genomics Centre · DECity University of New York · USGeorge Washington University · USHokkaido University · JPMayo Clinic · USNew York Hospital Queens · USRIKEN Advanced Science Institute · JPUniversity of Michigan–Ann Arbor · US

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
Epitomic Biomarkers of Prostate CancerU01CA111275 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M, RUBIN, MARK A. · 2004 to 2015
$6.8M
Comprehensive Prostate Cancer Characterization by Genomic and Transcriptomic ProfR01CA152057 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RUBIN, MARK A. · 2011 to 2013
$1.8M
NCATS NIH HHS UL1 TR000457NCATS NIH HHS UL1TR000457NCI NIH HHS R01 CA152057NCI NIH HHS U01 CA111275
6 · The paper itself

Abstract

The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR status. However, the role of ERα remains elusive. Using a combination of chromatin immunoprecipitation (ChIP) and RNA-sequencing data, we identified an ERα-specific non-coding transcriptome signature. Among putatively ERα-regulated intergenic long non-coding RNAs (lncRNAs), we identified nuclear enriched abundant transcript 1 (NEAT1) as the most significantly overexpressed lncRNA in prostate cancer. Analysis of two large clinical cohorts also revealed that NEAT1 expression is associated with prostate cancer progression. Prostate cancer cells expressing high levels of NEAT1 were recalcitrant to androgen or AR antagonists. Finally, we provide evidence that NEAT1 drives oncogenic growth by altering the epigenetic landscape of target gene promoters to favour transcription.

Indexed as

Epigenesis, GeneticAdenocarcinomaCell Line, TumorChromatin ImmunoprecipitationDisease ProgressionEstrogen Receptor alphaHumansMaleProstatic NeoplasmsRNA, Long NoncodingSequence Analysis, RNAESR1 protein, humanEstrogen Receptor alphaNEAT1 long non-coding RNA, humanRNA, Long Noncoding

Identifiers

PMID25415230
PMCPMC4241506
OpenAlexW2124826140

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.