Evidence map›Paper›PMID 25415198›Full record

ReviewViruses2014

Mosquito immunity against arboviruses.

Shuzhen Sim, Natapong Jupatanakul, George Dimopoulos

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 183 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Characterizing the Bacterial Microbiome of the Invasive VectorInternational journal of microbiology · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Epidemiology and infection · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Shuzhen SimGenome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore. shuzhens@gis.a-star.edu.sg.
Natapong JupatanakulHarry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA. njupata1@jhu.edu.
George DimopoulosHarry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA. gdimopo1@jhu.edu.
Johns Hopkins University · USGenome Institute of Singapore · SG

Funding

Targeting dengue in the mosquito with small moleculesR01AI101431 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE, ENGEL, DANIEL A · 2012 to 2016
$4.3M
The JAK-STAT pathway in anti-dengue defenseR21AI090188 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2010 to 2011
$448k
NIAID NIH HHS R01 AI101431NIAID NIH HHS R01AI101431NIAID NIH HHS R21 AI090188NIAID NIH HHS R21AI090188
6 · The paper itself

Abstract

Arthropod-borne viruses (arboviruses) pose a significant threat to global health, causing human disease with increasing geographic range and severity. The recent availability of the genome sequences of medically important mosquito species has kick-started investigations into the molecular basis of how mosquito vectors control arbovirus infection. Here, we discuss recent findings concerning the role of the mosquito immune system in antiviral defense, interactions between arboviruses and fundamental cellular processes such as apoptosis and autophagy, and arboviral suppression of mosquito defense mechanisms. This knowledge provides insights into co-evolutionary processes between vector and virus and also lays the groundwork for the development of novel arbovirus control strategies that target the mosquito vector.

Indexed as

Host-Pathogen InteractionsAnimalsApoptosisArbovirusesAutophagyBiological EvolutionCulicidaeImmune EvasionInsect Vectors

Identifiers

PMID25415198
PMCPMC4246235
OpenAlexW2027972205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.