ArticleSchizophrenia research. Cognition2014
WORKING MEMORY IMPAIRMENT AS AN ENDOPHENOTYPIC MARKER OF A SCHIZOPHRENIA DIATHESIS.
Article in Schizophrenia research. Cognition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder.Human brain mapping · 2021Pooled it
- Working memory circuit as a function of increasing age in healthy adolescence: A systematic review and meta-analyses.NeuroImage. Clinical · 2016Pooled it
- The impact of early intervention for first episode psychosis on cognitive functioning.Schizophrenia research · 2023Trial
- GlyT1 inhibition enhances working memory in the mouse TUNL task and normalizes NMDA antagonist-induced network activity.Psychopharmacology · 2026Article
- Central Obesity-related Brain Alterations Predict Cognitive Impairments in First Episode of Psychosis.Schizophrenia bulletin · 2026Observational
- Investigation of varenicline and tropisetron in latent inhibition and novel object recognition in mice.Scientific reports · 2026Article
- Visual suppression deficits as a biomarker of working memory impairment in schizophrenia.Schizophrenia research. Cognition · 2026Review
- ERP Decoding Analysis of Visual Working Memory Processes in Schizophrenia.Alpha psychiatry · 2026Article
- Classifying schizophrenia subtypes via resting-state EEG complexity networks.Scientific reports · 2025Article
- An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function.Molecular psychiatry · 2025Article
- An experimental and computational investigation of executive functions and inner speech in schizophrenia spectrum disorders.Scientific reports · 2025Article
- Task-related changes in aperiodic activity are related to visual working memory capacity independent of event-related potentials and alpha oscillations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Enhancing visual working memory in schizophrenia: effects of frontoparietal theta tACS in low-performing patients.Schizophrenia (Heidelberg, Germany) · 2024Article
- Disrupted cognitive network revealed by task-induced brain entropy in schizophrenia.Brain imaging and behavior · 2024Article
- Task-based default mode network connectivity predicts cognitive impairment and negative symptoms in first-episode schizophrenia.Psychophysiology · 2024Article
- Irregularity of visual motion perception and negative symptoms in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis.Schizophrenia bulletin · 2023Article
- Immediate post performance judgements about cognitive performance in schizophrenia and bipolar disorder: associations with test performance and subjective overall judgments regarding abilities.Cognitive neuropsychiatry · 2023Article
- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious Mental Illness (CNTRaCS) Consortium: Progress and Future Directions.Current topics in behavioral neurosciences · 2023Article
- Working Memory in People with Schizophrenia.Current topics in behavioral neurosciences · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
This chapter focuses on the viability of working memory impairment as an endophenotypic marker of a schizophrenia diathesis. It begins with an introduction of the construct of working memory. It follows with a review of the operational criteria for defining an endophenotype. Research findings regarding the working memory performance of schizophrenia and schizophrenia-spectrum patients, first-degree relatives of schizophrenia patients and healthy controls, are reviewed in terms of the criteria for being considered an endophenotypic marker. Special attention is paid to specific components of the working memory deficit (namely, encoding, maintenance, and manipulation), in terms of which aspects are likely to be the best candidates for endophenotypes. We consider the extant literature regarding working memory performance in bipolar disorder and major depression in order to address the issue of relative specificity to schizophrenia. Despite some unresolved issues, it appears that working memory impairment is a very promising candidate for an endophenotypic marker of a schizophrenia diathesis but not for mood disorders. Throughout this chapter, we identify future directions for research in this exciting and dynamic area of research and evaluate the contribution of working memory research to our understanding of schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.