Evidence map›Paper›PMID 25414746›Full record

ArticleJournal of human kinetics2014

Interaction Between ACE I/D and ACTN3 R557X Polymorphisms in Polish Competitive Swimmers.

Agata Grenda, Agata Leońska-Duniec, Mariusz Kaczmarczyk, Krzysztof Ficek, Paweł Król, Paweł Cięszczyk, Piotr Zmijewski

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human kinetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Role of theInternational journal of environmental research and public health · 2024
    Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Review
  8. Journal of human kinetics · 2021
    Article
  9. Article
  10. Association ofInternational journal of environmental research and public health · 2019
    Article
  11. Article
  12. Biology of sport · 2017
    Article
  13. Article
  14. Association of Angiotensin Converting Enzyme I/D and α-actinin-3 R577X Genotypes with Growth Factors and Physical Fitness in Korean Children.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Agata GrendaDepartment of Physical Education and Sport, West Pomeranian Technological University, Szczecin, Poland.
Agata Leońska-DuniecFaculty of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland.
Mariusz KaczmarczykFaculty of Tourism and Recreation, Academy of Physical Education and Sport, Gdansk, Poland.
Krzysztof FicekFaculty of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland.
Paweł KrólUniversity of Rzeszow, Department of Physical Culture, Rzeszow, Poland.
Paweł CięszczykFaculty of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland.
Piotr ZmijewskiInstitute of Sport in Warsaw, Poland.
University of Szczecin · PLGdansk University of Physical Education and Sport · PLInstytut Sportu · PLRzeszów University · PLWest Pomeranian University of Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We hypothesized that the ACE ID / ACTN3 R577X genotype combination was associated with sprint and endurance performance. Therefore, the purpose of the present study was to determine the interaction between both ACE ID and ACTN3 R577X polymorphisms and sprint and endurance performance in swimmers. Genomic DNA was extracted from oral epithelial cells using GenElute Mammalian Genomic DNA Miniprep Kit (Sigma, Germany). All samples were genotyped using a real-time poly- merase chain reaction. The ACE I/D and the ACTN3 R577X genotype frequencies met Hardy-Weinberg expectations in both swimmers and controls. When the two swimmer groups, long distance swimmers (LDS) and short distance swimmers (SDS), were compared with control subjects in a single test, a significant association was found only for the ACE polymorphism, but not for ACTN3. Additionally, four ACE/ACTN3 combined genotypes (ID/RX, ID/XX, II/RX and II/XX) were statistically significant for the LDS versus Control comparison, but none for the SDS versus Control comparison. The ACE I/D and the ACTN3 R577X polymorphisms did not show any association with sprint swimming, taken individually or in combination. In spite of numerous previous reports of associations with athletic status or sprint performance in other sports, the ACTN3 R577X polymorphism, in contrast to ACE I/D, was not significantly associated with elite swimming status when considered individually. However, the combined analysis of the two loci suggests that the co-occurrence of the ACE I and ACTN3 X alleles may be beneficial to swimmers who compete in long distance races.

Indexed as

ACEACTN3gene polymorphismswimming

Identifiers

PMID25414746
PMCPMC4234751
OpenAlexW2136220693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.