ArticleFrontiers in behavioral neuroscience2014
Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Stress Accelerates Depressive-Like Behavior through Increase of SPNS2 Expression in Tg2576 Mice.Biomolecules & therapeutics · 2025Article
- 1-methyl-tryptophan improves anxiety-like behavior in colitis mice by inhibiting neuroinflammation, promoting cell regeneration, and decreasing apoptosis.Clinical and experimental immunology · 2025Article
- Motor, mood, and memory impairments persist during remission periods in chronic colitis and are influenced by neuroinflammation and sex.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice.Translational psychiatry · 2024Article
- Acute gut inflammation reduces neural activity and spine maturity in hippocampus but not basolateral amygdala.Scientific reports · 2022Article
- Acute Colon Inflammation Triggers Primary Motor Cortex Glial Activation, Neuroinflammation, Neuronal Hyperexcitability, and Motor Coordination Deficits.International journal of molecular sciences · 2022Article
- Relationship between Mucosal Barrier Function of the Oviduct and Intestine in the Productivity of Laying Hens.The journal of poultry science · 2022Review
- RORγt-Expressing Pathogenic CD4Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease.Journal of neuroinflammation · 2022Review
- Pyrroloquinoline Quinone Regulates Enteric Neurochemical Plasticity of Weaned Rats Challenged With Lipopolysaccharide.Frontiers in neuroscience · 2022Article
- Partial recovery of voiding function in female mice following repeated psychological stress exposure.PloS one · 2022Article
- Tandospirone prevents stress-induced anxiety-like behavior and visceral hypersensitivity by suppressing theta oscillation enhancementFrontiers in cellular neuroscience · 2022Article
- The role of epigenetics in psychological resilience.The lancet. Psychiatry · 2021Review
- Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD).Molecular psychiatry · 2021Article
- Gut Inflammation Induced by Dextran Sulfate Sodium Exacerbates Amyloid-β Plaque Deposition in the AppNL-G-F Mouse Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis.Nutrients · 2020Article
- Neuropeptides in gut-brain axis and their influence on host immunity and stress.Computational and structural biotechnology journal · 2020Review
- Electro-Acupuncture Attenuates Chronic Stress ResponsesFrontiers in neuroscience · 2020Article
- Experimental colitis reduces microglial cell activation in the mouse brain without affecting microglial cell numbers.Scientific reports · 2019Article
- Exploring the involvement of Tac2 in the mouse hippocampal stress response through gene networking.Gene · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Inflammatory bowel disease is associated with an increased risk of mental disorders and can be exacerbated by stress. In this study which was performed with male 10-week old C57Bl/6N mice, we used dextran sulfate sodium (DSS)-induced colitis to evaluate behavioral changes caused by intestinal inflammation, to assess the interaction between repeated psychological stress (water avoidance stress, WAS) and colitis in modifying behavior, and to analyze neurochemical correlates of this interaction. A 7-day treatment with DSS (2% in drinking water) decreased locomotion and enhanced anxiety-like behavior in the open field test and reduced social interaction. Repeated exposure to WAS for 7 days had little influence on behavior but prevented the DSS-induced behavioral disturbances in the open field and SI tests. In contrast, repeated WAS did not modify colon length, colonic myeloperoxidase content and circulating proinflammatory cytokines, parameters used to assess colitis severity. DSS-induced colitis was associated with an increase in circulating neuropeptide Y (NPY), a rise in the hypothalamic expression of cyclooxygenase-2 mRNA and a decrease in the hippocampal expression of NPY mRNA, brain-derived neurotrophic factor mRNA and mineralocorticoid receptor mRNA. Repeated WAS significantly decreased the relative expression of corticotropin-releasing factor mRNA in the hippocampus. The effect of repeated WAS to blunt the DSS-evoked behavioral disturbances was associated with a rise of circulating corticosterone and an increase in the expression of hypothalamic NPY mRNA. These results show that experimental colitis leads to a particular range of behavioral alterations which can be prevented by repeated WAS, a model of predictable chronic stress, while the severity of colitis remains unabated. We conclude that the mechanisms underlying the resilience effect of repeated WAS involves hypothalamic NPY and the hypothalamic-pituitary-adrenal axis.
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