Evidence map›Paper›PMID 25414389›Full record

ReviewDiabetes care2014

The SEARCH for Diabetes in Youth study: rationale, findings, and future directions.

Richard F Hamman, Ronny A Bell, Dana Dabelea, Ralph B D'Agostino, Lawrence Dolan, Giuseppina Imperatore, Jean M Lawrence, Barbara Linder, Santica M Marcovina, Elizabeth J Mayer-Davis and 4 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 4 pooled it
39.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

235 citing papers in PubMed, 4 syntheses or guidelines pooled it, 613 citations in OpenAlex.

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175 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Richard F HammanDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO.
Ronny A BellDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC rbell@wakehealth.edu.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO.
Ralph B D'AgostinoDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
Lawrence DolanCincinnati Children's Hospital Medical Center, Cincinnati, OH.
Giuseppina ImperatoreDivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA.
Jean M LawrenceDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Barbara LinderChildhood Diabetes Research Division of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
Santica M MarcovinaNorthwest Lipid Research Laboratory, University of Washington, Seattle, WA.
Elizabeth J Mayer-DavisDepartment of Nutrition, University of North Carolina, Chapel Hill, NC Department of Medicine, University of North Carolina, Chapel Hill, NC.
Catherine PihokerDepartment of Pediatrics, University of Washington, Seattle, WA.
Beatriz L RodriguezJohn A. Burns School of Medicine, University of Hawaii, Kuakini Medical Center, Honolulu, HI Instituto Tecnologico de Monterrey, Monterrey, Mexico.
Sharon SaydahDivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA.
SEARCH for Diabetes in Youth Study Group
Centers for Disease Control and Prevention · USColorado School of Public Health · USUniversity of Washington · USWake Forest University · USCincinnati Children's Hospital Medical Center · USKaiser Permanente · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Hawaii System · USUniversity of North Carolina at Chapel Hill · US

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
SOUTH CAROLINA CLINICAL & TRANSLATIONAL RESEARCH INSTITUTE (SCTR)UL1RR029882 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2009 to 2011
$10.1M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
SEARCH for Diabetes in Youth Coordinating CenterU01DP000250 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BELL, RONNY A · 2005 to 2009
$4.8M
SEARCH For Diabetes in Youth, Phase 3: Cohort Study-Carolina CenterU18DP002708 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2010 to 2014
$3.6M
SEARCH for Diabetes in Youth 2: Colorado CenterU01DP000247 · DP · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2005 to 2009
$3.6M
SEARCH for Diabetes in Youth 2: South Carolina CenterU01DP000254 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2005 to 2009
$3.5M
SEARCH for Diabetes in Youth 3: Washington Site, Part BU18DP002710 · DP · SEATTLE CHILDREN'S HOSPITAL · PI PIHOKER, CATHERINE · 2010 to 2014
$3.2M
SEARCH 3 Cohort Study to Assess Incidence of Acute and Chronic Diabetes-related CU18DP002709 · DP · CINCINNATI CHILDRENS HOSP MED CTR · PI DOLAN, LAWRENCE M · 2010 to 2014
$3.2M
HSRD VA HIR 10-001NCATS NIH HHS 8-UL1-TR-000077NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1-TR-000154NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1-TR-000423NCCDPHP CDC HHS 1-U18-DP-002709NCCDPHP CDC HHS DP-05-069NCCDPHP CDC HHS DP-10-001NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01-DP-000244NCCDPHP CDC HHS U01 DP000245NCCDPHP CDC HHS U01-DP-000245NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01-DP-000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01-DP-000247NCCDPHP CDC HHS U01 DP000248NCCDPHP CDC HHS U01-DP-000248NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01-DP-000250NCCDPHP CDC HHS U01 DP000254NCCDPHP CDC HHS U01-DP-000254NCCDPHP CDC HHS U18-DP-000247-06A1NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18-DP-002708NCCDPHP CDC HHS U18 DP002709NCCDPHP CDC HHS U18 DP002710NCCDPHP CDC HHS U18-DP-002710-01NCCDPHP CDC HHS U18 DP002714NCCDPHP CDC HHS U18-DP-002714NCCDPHP CDC HHS U18 DP006134NCRR NIH HHS UL1 RR029882NCRR NIH HHS UL1-RR-029882NIDDK NIH HHS K23 DK089017NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK057516NIDDK NIH HHS P30-DK-057516NIDDK NIH HHS P30 DK093002PHS HHS 200-2010-35171PHS HHS PA NUMBERS 00097PHS HHS U48/CCU419249PHS HHS U48/CCU519239PHS HHS U48/CCU819241-3PHS HHS U48/CCU919219PHS HHS U58/CCU019235-4PHS HHS U58CCU919256
6 · The paper itself

Abstract

The SEARCH for Diabetes in Youth (SEARCH) study was initiated in 2000, with funding from the Centers for Disease Control and Prevention and support from the National Institute of Diabetes and Digestive and Kidney Diseases, to address major knowledge gaps in the understanding of childhood diabetes. SEARCH is being conducted at five sites across the U.S. and represents the largest, most diverse study of diabetes among U.S. youth. An active registry of youth diagnosed with diabetes at age <20 years allows the assessment of prevalence (in 2001 and 2009), annual incidence (since 2002), and trends by age, race/ethnicity, sex, and diabetes type. Prevalence increased significantly from 2001 to 2009 for both type 1 and type 2 diabetes in most age, sex, and race/ethnic groups. SEARCH has also established a longitudinal cohort to assess the natural history and risk factors for acute and chronic diabetes-related complications as well as the quality of care and quality of life of persons with diabetes from diagnosis into young adulthood. Many youth with diabetes, particularly those from low-resourced racial/ethnic minority populations, are not meeting recommended guidelines for diabetes care. Markers of micro- and macrovascular complications are evident in youth with either diabetes type, highlighting the seriousness of diabetes in this contemporary cohort. This review summarizes the study methods, describes key registry and cohort findings and their clinical and public health implications, and discusses future directions.

Indexed as

RegistriesAdolescentAdultAge of OnsetCenters for Disease Control and Prevention, U.S.Cohort StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansIncidenceMalePrevalenceUnited StatesYoung Adult

Identifiers

PMID25414389
PMCPMC4237981
OpenAlexW2058667229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.