ArticleNucleic acids research2014
Atomic force microscopy study of DNA flexibility on short length scales: smooth bending versus kinking.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Systematic Comparison of Atomistic Force Fields for the Mechanical Properties of Double-Stranded DNA.Journal of chemical theory and computation · 2024Article
- Accurate Sequence-Dependent Coarse-Grained Model for Conformational and Elastic Properties of Double-Stranded DNA.Journal of chemical theory and computation · 2022Article
- Article
- Mechanical Flexibility of DNA: A Quintessential Tool for DNA Nanotechnology.Sensors (Basel, Switzerland) · 2020Review
- Article
- Resolution-Free Accurate DNA Contour Length Estimation from Atomic Force Microscopy Images.Scanning · 2019Article
- Mechanism of formation of a toroid around DNA by the mismatch sensor protein.Nucleic acids research · 2018Article
- Long-timescale dynamics of the Drew-Dickerson dodecamer.Nucleic acids research · 2016Article
- DNA studies using atomic force microscopy: capabilities for measurement of short DNA fragments.Frontiers in molecular biosciences · 2015Review
- Simulation Assisted Analysis of the Intrinsic Stiffness for Short DNA Molecules Imaged with Scanning Atomic Force Microscopy.PloS one · 2015Article
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Authors and funding
2 authors.
Funding
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Abstract
The apparently anomalous flexibility of DNA on short length scales has attracted a lot of attention in recent years. We use atomic force microscopy (AFM) in solution to directly study the DNA bending statistics for small lengths down to one helical turn. The accuracy of experimental estimates could be improved due to a large data volume and a refined algorithm for image processing and measuring bend angles. It is found that, at length scales beyond two helical turns (7 nm), DNA is well described by the harmonic worm-like chain (WLC) model with the bending persistence length of 56 nm. Below this threshold, the AFM data are also described by the WLC model assuming that the accuracy of measured bend angles is limited by the physical width of the double helix. We conclude that the double helical DNA behaves as a uniform elastic rod even at very short length scales. Strong bends due to kinks, melting bubbles and other deviations from the WLC model are statistically negligible.
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