ArticleInvestigative ophthalmology & visual science2014
Abnormal activity of neurons in abducens nucleus of strabismic monkeys.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Saccade-Related Activity in Superior Colliculus Predicts Eye Choice for Goal-Directed Saccades in Monkeys With Strabismus.Investigative ophthalmology & visual science · 2025Article
- Disconjugacies of saccade duration and trajectories in strabismus.Strabismus · 2024Article
- Microstimulation of Interstitial Nucleus of Cajal Evokes Directionally Disconjugate Eye Movements in Monkeys With Pattern Strabismus.Investigative ophthalmology & visual science · 2022Article
- Abnormal Tuning in Nucleus Prepositus Hypoglossi of Monkeys With "A" Pattern Exotropia.Investigative ophthalmology & visual science · 2020Article
- Response Properties of Cells Within the Rostral Superior Colliculus of Strabismic Monkeys.Investigative ophthalmology & visual science · 2019Article
- Abnormal Eye Position Signals in Interstitial Nucleus of Cajal in Monkeys With "A" Pattern Strabismus.Investigative ophthalmology & visual science · 2019Article
- A Rhesus Monkey With a Naturally Occurring Impairment of Disparity Vergence. II. Abnormal Near Response Cell Activity in the Supraoculomotor Area.Investigative ophthalmology & visual science · 2019Article
- Horizontal Saccadic Velocity in Patients with Exotropia before and after Unilateral Resection and Recession Surgery.Journal of ophthalmology · 2019Article
- Neural Plasticity Following Surgical Correction of Strabismus in Monkeys.Investigative ophthalmology & visual science · 2018Article
- Visualizing Neuronal Adaptation Over Time After Treatment of Strabismus.Investigative ophthalmology & visual science · 2018Article
- Electrical stimulation of superior colliculus affects strabismus angle in monkey models for strabismus.Journal of neurophysiology · 2017Article
- Normal correspondence of tectal maps for saccadic eye movements in strabismus.Journal of neurophysiology · 2016Article
- Longitudinal Evaluation of Eye Misalignment and Eye Movements Following Surgical Correction of Strabismus in Monkeys.Investigative ophthalmology & visual science · 2016Article
- Improvement of Eye Alignment in Adult Strabismic Monkeys by Sustained IGF-1 Treatment.Investigative ophthalmology & visual science · 2016Article
- Strabismus and the Oculomotor System: Insights from Macaque Models.Annual review of vision science · 2016Article
- Electrical Microstimulation of the Superior Colliculus in Strabismic Monkeys.Investigative ophthalmology & visual science · 2016Article
- Abnormal tuning of saccade-related cells in pontine reticular formation of strabismic monkeys.Journal of neurophysiology · 2015Article
- Cross-coupled eye movement supports neural origin of pattern strabismus.Investigative ophthalmology & visual science · 2015Article
- Childhood Onset Strabismus: A Neurotrophic Factor Hypothesis.Journal of binocular vision and ocular motilityArticle
- Dynamic Electrooculography Findings for Medial Rectus Myofascial Release in Esodeviation.Journal of current ophthalmologyArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeInfantile strabismus is characterized by persistent misalignment of the eyes. Mounting evidence suggests that the disorder is associated with abnormalities at the neural level, but few details are known. This study investigated the signals carried by abducens neurons in monkeys with experimentally induced strabismus. We wanted to know whether the firing rates of individual neurons are exclusively related to the position and velocity of one eye and whether the overall level of activity of the abducens nucleus was in the normal range.
methodsWe recorded 58 neurons in right and left abducens nuclei while strabismic monkeys (one esotrope and one exotrope) performed a saccade task. We analyzed the firing rates associated with static horizontal eye position and saccades by fitting the data with a dynamic equation that included position and velocity terms for each eye. Results were compared to previously published data in normal monkeys.
resultsFor both strabismic monkeys the overall tonic activity was 50 to 100 spikes/s lower, for every suprathreshold eye position, than what has previously been reported for normal monkeys. This was mostly the result of lower baseline activity; the slopes of rate-position curves were similar to those in previous reports in normal monkeys. The saccade velocity sensitivities were similar to those of normal monkeys, 0.35 for the esotrope and 0.40 for the exotrope. For most neurons the firing rate was more closely related to the position and velocity of the ipsilateral eye.
conclusionsThese data suggest that strabismus can be associated with reduced neural activity in the abducens nucleus.
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